Search

Displaying results 5581 - 5590 of 10000 in total
  1. Drug

    Simeprevir

    go.drugbank.com/drugs/DB06290
    ApprovedWithdrawn

    Broad use of simeprevir occurred when it was used in combination with a newer drug, [DB08934]. … Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection.

    Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsProducts: OLYSIO 150 MG KAPSUL ,KAPSUL, 28 ADET
  2. Drug

    Pentamidine

    go.drugbank.com/drugs/DB00738
    ApprovedInvestigational

    It may cause diabetes mellitus, central nervous system damage, and other toxic effects. … Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients.

    Synonyms: p,p'-(pentamethylenedioxy)dibenzamidine, 1,5-bis(4-amidinophenoxy)pentaneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    Boceprevir

    go.drugbank.com/drugs/DB08873
    ApprovedWithdrawn

    Boceprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) do not reccomend Boceprevir in combination

    Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)
  4. Drug

    Isavuconazole

    go.drugbank.com/drugs/DB11633
    ApprovedInvestigational

    has a potential for nephrotoxicity [A32029]. … It is proposed that the intravenous and oral dosing can be used interchangeably [L1482], without the need for a repeat loading dose when transitioning from an IV to an oral formulation [A32026].

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: CRESEMBA (100 MG HARD CAPSULES), CRESEMBA (POWDER FOR SOLUTION FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200 MG/VIAL)
  5. Drug

    Cobalt

    go.drugbank.com/drugs/DB14574
    ApprovedWithdrawn

    A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. … Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.

    Products: Cobalt - Liq. 29.5 Mcg/ml
  6. Drug

    Minocycline

    go.drugbank.com/drugs/DB01017
    ApprovedInvestigational

    Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. … [A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.

    Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamideProducts: XELTETRA-M, Udima 50 mg - Kapseln
  7. Drug

    Lutetium Lu-177 vipivotide tetraxetan

    go.drugbank.com/drugs/DB16778
    ApprovedInvestigational

    It consists of a radionuclide, [lutetium Lu-177], linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer. … Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent.

    Synonyms: Lu-177-PSMA-617, lutetium Lu 177-PSMA-617Categories: Compounds used in a research, industrial, or household setting
  8. Target

    1-aminocyclopropane-1-carboxylate synthase-like protein 1

    go.drugbank.com/bio_entities/BE0003515
    TargetHumans

    Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine

    Polypeptides: 1-aminocyclopropane-1-carboxylate synthase-like protein 1Synonyms: ACC synthase-like protein 1
  9. Drug

    Crizotinib

    go.drugbank.com/drugs/DB08865
    ApprovedInvestigational

    Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic … [L42460] By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers robust effectiveness in treating NSCLC in patients with this type of rearrangement

    Synonyms: (R)-crizotinibCategories: Heterocyclic Compounds, 1-Ring, Organic Cation Transporter 1 Inhibitors
  10. Drug

    Mertiatide

    go.drugbank.com/drugs/DB15780
    Investigational

    Products: Mertioscan 0,2 mg Kit für ein radioaktives Arzneimittel, NEPHROMAG EQUIPOS DE REACTIVOS PARA PREPARACION RADIOFARMACEUTICA.