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Displaying results 5811 - 5820 of 10000 in total
  1. Drug

    Efalizumab

    go.drugbank.com/drugs/DB00095
    ApprovedWithdrawn

    Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. … It was later withdrawn in 2009 due to a potential risk of progressive multifocal leukoencephalopathy (PML).[L43797]

    Products: RAPTIVA ®125 MG
  2. Drug

    Choriogonadotropin alfa

    go.drugbank.com/drugs/DB00097
    ApprovedInvestigational

    Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN … The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH.

    Products: OVITRELLE 250 MCG/0,5 ML KULLANIMA HAZIR ŞIRINGADA ENJEKSİYONLUK ÇÖZELTİ, 1 ADET
  3. Drug

    Antithymocyte immunoglobulin (rabbit)

    go.drugbank.com/drugs/DB00098
    ApprovedInvestigational

    Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells. … Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients.

    Synonyms: r-ATG, Lapine T-lymphocyte immune globulinInternational brands: ATG-Fresenius S
  4. Drug

    Filgrastim

    go.drugbank.com/drugs/DB00099
    ApprovedInvestigational

    It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_. … [L40714] Human G-CSF is a glycoprotein that regulates the production and release of neutrophils from the bone marrow.

    Synonyms: r-metHuG-CSFInternational brands: White-C
  5. Drug

    Natalizumab

    go.drugbank.com/drugs/DB00108
    ApprovedInvestigational

    Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin.

    Synonyms: IMMUNOGLOBULIN G4 (HUMAN-MOUSE MONOCLONAL AN100226 4-CHAIN ANTI-HUMAN INTEGRIN 4), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL AN100226 LIGHT CHAIN, DIMER, IMMUNOGLOBULIN G4 (HUMAN-MOUSE MONOCLONAL AN100226 4-CHAIN ANTI-HUMAN INTEGRIN 4), DISULPHIDE WITH HUMAN-MOUSE MONOCLONAL AN100226 LIGHT CHAIN, DIMERProducts: TYSABRI®, TYSABRI® SUBCUTÁNEO 150MG/ML
  6. Drug

    Cyanocobalamin

    go.drugbank.com/drugs/DB00115
    ApprovedInvestigationalNutraceutical

    Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt.

    International brands: Cobolin-M, Neuroforte-RMixtures: Formula F L W, B Complex W C Forte Cap
  7. Drug

    Ipratropium

    go.drugbank.com/drugs/DB00332
    ApprovedInvestigational

    [A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. … Ipratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic agent.

    Mixtures: BERODUAL® HFA, BERODUAL® HFAProducts: Atrovent ® 0.025% Nebuliser Solution, BRIA®
  8. Drug

    Phenylpropanolamine

    go.drugbank.com/drugs/DB00397
    ApprovedVet approvedWithdrawn

    Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. … It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.

    Mixtures: TERA F, TERA FCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Adrenergic beta-2 Receptor Agonists
  9. Drug

    Nabilone

    go.drugbank.com/drugs/DB00486
    ApprovedInvestigational

    Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. … Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana).

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: Canemes 1 mg Kapseln
  10. Drug

    Vincristine

    go.drugbank.com/drugs/DB00541
    ApprovedInvestigational

    Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for th...

    Mixtures: MEODEX®, MEODEX®Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index