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Afimetoran

[L32018, L32023] It is also is under investigation in clinical trial NCT04269356 (Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986256 in Healthy Male … Afimetoran is an immunomodulator and an antagonist of toll-like receptors 7 and 8.

NRP290

NRP290 is a hydrocodone derivative under investigation for the treatment of pain (moderate to moderately severe).

Alefacept

Produced by CHO cells, mW is 91.4 kD.

rhGAD65

rhGAD65 (recombinant human glutamic acid decarboxylase) is a vaccine being developed to treat insulin dependent type 1 diabetes.

Biapenem

Biapenem has been used in trials studying the treatment of various bacterial infections. … It is a carbapenem antibiotic with a methyl group on the 1-beta position, which gives it stability against degradation by dehydropeptidase I.[A275008]

NKG2D-ACE2 CAR-NK Cell

The ACE2 is a receptor for SARS-Cov-2, binding to the S-protein of the viral envelope and competitively inhibiting SARS-Cov-2 infection of type II alveolar epithelial cells. … These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF.

Vadimezan

OP-145

OP-145 is a synthetic antimicrobial peptide developed from human cathelicidin LL-37.

Bafilomycin A1

These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). … The most commonly utilized bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

KD7040

KD7040 is a topically-delivered inducible nitric oxide synthase (iNOS) inhibitor for the treatment of neuropathic pain. The KD7040 IND was filed in 4Q06, and a Phase Ib clinical trial began 2Q07. … It is being developed by Kalypsys.