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Dexchlorpheniramine maleate
go.drugbank.com/drugs/DB09555ApprovedDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Mixtures: Corzall PE, Polytussin DMCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsLumateperone
go.drugbank.com/drugs/DB06077ApprovedInvestigational[A189093,A189174] The data so far indicates that lumateperone can alleviate both positive and negative symptoms of schizophrenia. … [A189093] Further, not only is the new antipsychotic selective for dopamine (D2) receptors in the mesolimbic and mesocortical brain regions, but it also has minimal off-target activity.
Categories: Dopamine D2 Receptor Agonists, Cytochrome P-450 SubstratesEnsulizole
go.drugbank.com/drugs/DB11115ApprovedDue to its water solubility, ensulizole is commonly used in products formulated to feel light and less oily [A32259]. … It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths.
Mixtures: Myung Han Miindo Make Up Base, Radiance Superbe Day Cream Neutral TanProducts: Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 857 Golden Tan, Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 860 Classic TanMitapivat
go.drugbank.com/drugs/DB16236ApprovedInvestigational[A245478] On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesThioproperazine
go.drugbank.com/drugs/DB01622ApprovedThioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually ...
Categories: Dopamine D2 Receptor AntagonistsPipotiazine
go.drugbank.com/drugs/DB01621ApprovedInvestigationalWithdrawnPipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depr...
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesZoledronic acid
go.drugbank.com/drugs/DB00399ApprovedInvestigationalZoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hype...
Salts: Zoledronate D,L-Lysine MonohydrateProducts: ASZORA TRIO CA+D3 4MG/100, ASZORA TRIO CA+D3 4MG/5MLOrnidazole
go.drugbank.com/drugs/DB13026InvestigationalOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
Products: TIBERAL ROCHE DE 500 MGNalmefene
go.drugbank.com/drugs/DB06230ApprovedInvestigationalWithdrawn[L40684] It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor. … Nalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigationalNirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CL<sup>PRO</sup>) inhibitor that is the subject of clinical trial NCT04756531. … [L33359] Nirmatrelvir is advantageous in that it can be prescribed to patients before they require hospitalization, while [PF-07304814] requires intravenous administration in hospital.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates