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Nilvadipine
go.drugbank.com/drugs/DB06712ApprovedNilvadipine is a calcium channel blocker (CCB) for the treatment of hypertension.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: Tensan retard 8 mg - KapselnAniline
go.drugbank.com/drugs/DB06728InvestigationalConsisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. … Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesSynonyms: Fentanyl impurity F, Trimethoprim specified impurity KGestodene
go.drugbank.com/drugs/DB06730InvestigationalGestodene is a progestogen hormonal contraceptive.
Mixtures: FEMIANE®, FEMIANE®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitorsbeta-Naphthoflavone
go.drugbank.com/drugs/DB06732Experimentalβ-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). … It may be a chemopreventive agent.
Categories: Cytochrome P-450 CYP1A2 Inducers, Heterocyclic Compounds, 1-RingSynonyms: 3-phenyl-1H-naphtho(2,1-b)pyran-1-one, β-NFBafilomycin A1
go.drugbank.com/drugs/DB06733ExperimentalBafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most commonly utilized bafilomycin is bafilomycin A1. … The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus.
Zaltoprofen
go.drugbank.com/drugs/DB06737InvestigationalA non-steroidal anti-inflammatory drug approved for use in Japan in 1993.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSBW-A 58C
go.drugbank.com/drugs/DB06740ExperimentalBW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy … metabolite in man in vivo and also in human liver microsomes, where this is catalysed primarily by a 54 kDa CYP2C9 form of cytochrome P450, P450hB20-27.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsSynonyms: 2-(4'-t-Butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinoneGavestinel
go.drugbank.com/drugs/DB06741ExperimentalHighly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM).
Categories: Heterocyclic Compounds, 2-RingDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnDanaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans [A32565]. … Danaparoid possesses a potent antithrombic activity that works by inhibiting activated factor X (Factor Xa) and activated factor II (Factor IIa).
Sacrosidase
go.drugbank.com/drugs/DB06760ApprovedTreatment options for these patients are limited and usually consists of a lifelong sucrose-free diet; therefore, sacrosidase offers a potential alternative for symptom relief. … Sacrosidase is a liquid enzyme preparation from S.cerevisiae used for the treatment of congenital sucrose-isomaltase deficiency (CSID).