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Hepatitis B immune globulin
go.drugbank.com/drugs/DB05276ApprovedInvestigationalLong-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. … Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines.
Synonyms: Hepatitis B immune globulin, Hepatitis B immune globulin humanCategories: hepatitis B immunoglobulinNo catch-up growth by age 2 to 4 years
go.drugbank.com/conditions/DBCOND0136498Drugs: SomatotropinSynonyms: No catch-up growth by age 2 to 4 yearsEstradiol valerate
go.drugbank.com/drugs/DB13956ApprovedInvestigationalVet approvedHowever, after menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. … First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a chance to enter systemic circulation and exert its estrogenic effects [A12102].
Mixtures: CYCLO PROGYNOVA N 2MG/0.15, CYCLO PROGYNOVA N 2MG/0.15Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesDigoxin
go.drugbank.com/drugs/DB00390ApprovedInvestigational[L9143] This drug originates from the foxglove plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and botanist in the 1780s. … [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.
Categories: Compounds used in a research, industrial, or household setting, P-glycoprotein substrates with a Narrow Therapeutic IndexInternational brands: Digocard-GCAR BCMA-CS1
go.drugbank.com/drugs/DB17313ExperimentalCAR BCMA-CS1 is a lentiviral transfected chimeric antigen receptor (CAR) T-cell therapy modified to target B-cell maturation antigen and CS1.
Synonyms: CAR BCMA-CS1, BCMA-CS1 cCAR T cell therapyLevetiracetam
go.drugbank.com/drugs/DB01202ApprovedInvestigational[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: 6-UR, EPI-NO 250 MG FILM TABLET, 50 ADETValproic acid
go.drugbank.com/drugs/DB00313ApprovedInvestigationalValproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. … In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects of khelline when he found that all of his samples, dissolved in valproic acid, exerted
Synonyms: 2-n-propyl-n-valeric acid, n-DPAMixtures: Depakine Chronosphere 50 mg Retardgranulat in Beuteln, Depakine Chronosphere 50 mg Retardgranulat in BeutelnAllogeneic Cardiosphere-Derived Cells
go.drugbank.com/drugs/DB15744InvestigationalThey exert their effects by secreting exosomes: nanometer-sized, membrane-bound vesicles used for the purpose of cell-cell communication. … TNFa, IFN-y, IL-1B, and IL-15). The anti-inflammatory effects of CDC work through polarizing macrophages and restoring tissue function.
Synonyms: CAP-1002A, CAP-1002BDexpanthenol
go.drugbank.com/drugs/DB09357ApprovedInvestigationalDexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism … Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium.
Synonyms: (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, D-panthenolMixtures: Tini-cal Ampoules, K-FENIDEX JEL 30 GRecombinant Bacterial ACE2 Receptors-like Enzyme
go.drugbank.com/drugs/DB15741InvestigationalB38-CAP is structured as a carboxypeptidase and derived from _Paenibacillus sp._ The molecule, an Angiotensin Converting Enzyme 2 (ACE2)-like enzyme, shares structural similarities to the mammalian ACE2 … B38-CAP is an ACE2-like enzyme which decreases angiotensin II levels. It is being investigated for treating hypertension, myocardial fibrosis, and cardiac dysfunction.
Synonyms: B38-CAP