Dexpanthenol
Identification
- Summary
Dexpanthenol is an alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).
- Brand Names
- Fortaplex, Infuvite, Infuvite Pediatric, Mvi Pediatric, Neo-bex
- Generic Name
- Dexpanthenol
- DrugBank Accession Number
- DB09357
- Background
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium2.
Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 3.
Dexpanthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as Panthenol. While pantothenic acid is optically active, only the dextrorotatory form (dexpanthenol) is biologically active.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 205.2515
Monoisotopic: 205.131408101 - Chemical Formula
- C9H19NO4
- Synonyms
- (+)-Panthenol
- (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
- Bepanthen
- Bepanthene
- Bepantol
- D-panthenol
- D-panthenol 50
- D-Pantothenol
- D-Pantothenyl alcohol
- D(+)-Panthenol
- Dexpantenol
- Dexpanthenol
- Dexpanthenolum
- Pantol
- Pantothenyl alcohol
- Provitamin B
- External IDs
- 201-327-3
- BAY 81-2996
- NSC-302962
Pharmacology
- Indication
Injection: Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus. Intestinal atony causing abdominal distention; postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility; paralytic ileus.
Topical: This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy).
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Allergic Rhinitis (AR)
- Bursitis
- Canker Sore
- Contusions
- Dermabrasion
- Diaper Rash
- Dry Skin
- Edema
- Hoarseness
- Inflammation
- Inflammation of Mouth
- Insect Bites
- Lateral Epicondylitis
- Lesions of the Mucous Membranes
- Nasal Congestion
- Pharyngeal inflammation
- Pruritus
- Recurrent Upper and Lower Respiratory Tract Infections (RTIs)
- Seasonal Allergic Rhinitis
- Sinusitis
- Skin Roughness
- Sore Throat
- Sunburn
- Tendinitis
- Tooth Extraction Site Healing
- Traumatic Injuries caused by Dental Prosthesis
- Urticaria
- Vitamin Deficiency
- Wounds caused by Surgery, Oral of the Tonsils
- Dry, cracked skin
- Dryness of the nose
- Superficial Conjunctival injuries
- Superficial Corneal injuries
- Superficial Traumatic Injuries of the Nasal Mucosa
- Superficial Wounds
- Associated Therapies
- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
- Pharmacodynamics
Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.
- Mechanism of action
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium2.
Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 3.
- Absorption
Dexpanthenol is soluble in water and alcohol, although insoluble in fats and oil based substances. With the appropriate vehicle, Dexpanthenol is easily penetrated into the skin. Rate of penetration and absorption is reduced when Dexpanthenol is administered as an oil/water formula.
- Volume of distribution
Dexpanthenol is readily converted to pantothenic acid which is widely distributed into body tissues, mainly as coenzyme A. Highest concentrations are found in the liver, adrenal glands, heart, and kidneys.
- Protein binding
Plasma protein binding have not been reported.
- Metabolism
Dexpanthenol is readily converted to pantothenic acid which is widely distributed into body tissues, mainly as coenzyme A.
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- Route of elimination
Milk of nursing mothers receiving a normal diet contains about 2 ug of pantothenic acid per mL. About 70% of an oral dose of pantothenic acid is excreted unchanged in urine and about 30% in feces.
- Half-life
Half life have not been reported
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Mouse LD50 : 9gm/kg (Intraperitoneal) Mouse: LD50 7gm/kg (Intravenous) Mouse: LD50 15gm/kg (Oral) Rabbit LD50 4gm/kg (Oral)
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Acetaminophen Acetaminophen may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Dexpanthenol which could result in a lower serum level and potentially a reduction in efficacy. Acetyldigitoxin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Dexpanthenol is combined with Acetyldigitoxin. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Aclidinium Aclidinium may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Acrivastine Dexpanthenol may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Pantothenic acid unknown 19F5HK2737 79-83-4 GHOKWGTUZJEAQD-ZETCQYMHSA-N - International/Other Brands
- Cozyme / Ilopan / Motilyn / Panadon / Panthoderm / Synapan / Thenalton / Zentinic
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Dexpanthenol Injection, solution 250 mg/1mL Intramuscular; Intravenous American Regent 1993-08-20 2016-11-09 US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Babysons Ointment 50 mg/1g Topical Laboratorios Quimica Son's, S.A. de C.V 2020-06-15 Not applicable US BEPANTHEN OINTMENT Ointment Topical BAYER CO. (MALAYSIA) SDN. BHD. 2020-09-08 Not applicable Malaysia Eros Aqua Sensations and Care Woman Gel 0.5 g/100mL Topical MEGASOL COSMETIC GMBH 2012-10-01 2018-01-17 US MAR PLUS 5% NASAL SPRAY Solution; Spray 50 mg/1mL Nasal บริษัท สตาดา (ประเทศไทย) จำกัด 2014-08-21 Not applicable Thailand Perfect Pore Clean I Liquid 0.001 g/1mL Topical Ami Cosmetic Co.,Ltd. 2014-04-14 2019-01-15 US Vitalizer White Liquid 0.0005 g/1mL Topical Ami Cosmetic Co.,Ltd. 2014-04-14 2019-01-15 US Yozum Well Being Hair Color Liquid 0.2 g/100g Topical Yozum Korea 2014-12-08 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Adult Infuvite Multiple Vitamins Dexpanthenol (15 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2005-05-18 Not applicable US Adult Infuvite Multiple Vitamins Dexpanthenol (15 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2005-05-18 Not applicable US Adult Infuvite Multiple Vitamins Dexpanthenol (15 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2003-06-16 Not applicable US Adult Infuvite Multiple Vitamins Dexpanthenol (15 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2003-06-16 Not applicable US Alsimine W Vitamins A D Dexpanthenol (5 mg / amp) + Dexpanthenol (400 unit / amp) + Calcium glycerophosphate (13 mg / amp) + Cyanocobalamin (10 mcg / amp) + Ferrous gluconate (16 mg / amp) + Riboflavin-5'-phosphate sodium salt dihydrate (2 mg / amp) + Nicotinamide (40 mg / amp) + Pyridoxine hydrochloride (3 mg / amp) + Thiamine hydrochloride (4.5 mg / amp) + Vitamin A (10000 unit / amp) Capsule; Liquid Oral Alsi Cie Ltee 1978-12-31 2003-05-21 Canada Alsimine W Vitamins A D Dexpanthenol (5 mg / amp) + Dexpanthenol (400 unit / amp) + Calcium glycerophosphate (13 mg / amp) + Cyanocobalamin (10 mcg / amp) + Ferrous gluconate (16 mg / amp) + Riboflavin-5'-phosphate sodium salt dihydrate (2 mg / amp) + Nicotinamide (40 mg / amp) + Pyridoxine hydrochloride (3 mg / amp) + Thiamine hydrochloride (4.5 mg / amp) + Vitamin A (10000 unit / amp) Capsule; Liquid Oral Alsi Cie Ltee 1978-12-31 2003-05-21 Canada Aquasol A Cream Dexpanthenol (21.4 mg / g) + Vitamin A palmitate (7055 unit / g) Cream Topical Rhone Poulenc Rorer 1993-12-31 1998-08-12 Canada Atomy Herbal Hair Tonic Dexpanthenol (0.4 mL/200mL) + Levomenthol (0.6 mL/200mL) + Salicylic acid (0.5 mL/200mL) Liquid Topical Atomy Co., Ltd. 2010-04-29 Not applicable US B Complex W C and B12 Inj Dexpanthenol (60 mg / 10 mL) + Ascorbic acid (500 mg / 10 mL) + Cyanocobalamin (10 mg / 10 mL) + Riboflavin-5'-phosphate sodium salt dihydrate (50 mg / 10 mL) + Nicotinamide (1.25 g / 10 mL) + Pyridoxine hydrochloride (50 mg / 10 mL) + Thiamine hydrochloride (500 mg / 10 mL) Liquid Intramuscular; Intravenous E L Stickley And Co Ltd. 1963-12-31 1996-09-09 Canada B Vitamin Compound With B12 Thunas Dexpanthenol (.5 mg / mL) + Cyanocobalamin (.11 mcg / mL) + Nicotinamide (.8 mg / mL) + Riboflavin (.15 mg / mL) + Thiamine mononitrate (.15 mg / mL) Liquid Oral Thuna Herbal Remedies Ltd. 1984-05-31 2002-10-16 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Atomy Herbal Hair Tonic Dexpanthenol (0.4 mL/200mL) + Levomenthol (0.6 mL/200mL) + Salicylic acid (0.5 mL/200mL) Liquid Topical Atomy Co., Ltd. 2010-04-29 Not applicable US B-Combo Dexpanthenol (1 mg/1mL) + Mecobalamin (1 mg/1mL) + Nicotinamide (1 mg/1mL) + Pyridoxine (1 mg/1mL) + Riboflavin (1 mg/1mL) + Thiamine chloride (1 mg/1mL) Injection Intramuscular Perdido Key Health And Wellness Inc 2015-11-23 Not applicable US B-plex 100 Dexpanthenol (2 mg/1mL) + Riboflavin-5'-phosphate sodium salt dihydrate (2 mg/1mL) + Nicotinamide (100 mg/1mL) + Pyridoxine hydrochloride (2 mg/1mL) + Thiamine hydrochloride (100 mg/1mL) Injection, solution Intramuscular; Intravenous Merit Pharmaceutical 2012-01-01 Not applicable US BEHEPTAL 2 ML AMPUL, 5 ADET Dexpanthenol (500 mg) Solution OSEL İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey Black Repair Hair Boosting Tonic Dexpanthenol (0.2 g/100mL) + Menthol (0.3 g/100mL) + Salicylic acid (0.25 g/100mL) Liquid Topical DERMA CENTRIC INC 2021-03-28 Not applicable US Ch6 Greenol Herb Aloforthya Deep Forest Dexpanthenol (0.2 g/100mL) + Nicotinamide (0.1 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Rea Company 2022-10-01 Not applicable US Ch6 Greenol Herb Aloforthya Greentea Wood Dexpanthenol (0.2 g/100mL) + Nicotinamide (0.1 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Rea Company 2022-10-01 Not applicable US Ch6 Greenol Herb Aloforthya White Citrus Dexpanthenol (0.2 g/100mL) + Nicotinamide (0.1 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Rea Company 2022-10-01 Not applicable US Ch6 Greenol Herb Hair Control Non Wash Treatment Dexpanthenol (0.2 g/100mL) + Levomenthol (0.3 g/100mL) + Salicylic acid (0.25 g/100mL) Liquid Topical Rea Company 2022-10-01 Not applicable US CH6 Perfumed Aloforthya Aromatic herb Dexpanthenol (0.2 g/100mL) + Nicotinamide (0.1 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Rea Company 2022-09-01 Not applicable US
Categories
- ATC Codes
- D03AX03 — Dexpanthenol
- D03AX — Other cicatrizants
- D03A — CICATRIZANTS
- D03 — PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
- D — DERMATOLOGICALS
- S01XA — Other ophthalmologicals
- S01X — OTHER OPHTHALMOLOGICALS
- S01 — OPHTHALMOLOGICALS
- S — SENSORY ORGANS
- Drug Categories
- Alanine
- Alimentary Tract and Metabolism
- Amino Acids
- Amino Acids, Peptides, and Proteins
- Cicatrizants
- Dermatologicals
- Drugs that are Mainly Renally Excreted
- Imides
- Ophthalmologicals
- Preparations for Treatment of Wounds and Ulcers
- Sensory Organs
- Vitamin B Complex
- Vitamin D and Analogues
- Vitamins
- Vitamins (Fat Soluble)
- Wound Healing
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as secondary alcohols. These are compounds containing a secondary alcohol functional group, with the general structure HOC(R)(R') (R,R'=alkyl, aryl).
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Alcohols and polyols
- Direct Parent
- Secondary alcohols
- Alternative Parents
- Propargyl-type 1,3-dipolar organic compounds / Carboximidic acids / Alkanolamines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Aliphatic acyclic compound / Alkanolamine / Carboximidic acid / Carboximidic acid derivative / Hydrocarbon derivative / Organic 1,3-dipolar compound / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound / Primary alcohol
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- monocarboxylic acid amide, amino alcohol (CHEBI:27373)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1O6C93RI7Z
- CAS number
- 81-13-0
- InChI Key
- SNPLKNRPJHDVJA-ZETCQYMHSA-N
- InChI
- InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1
- IUPAC Name
- (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
- SMILES
- CC(C)(CO)[C@@H](O)C(=O)NCCCO
References
- General References
- Slyshenkov VS, Dymkowska D, Wojtczak L: Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004 Jul 2;569(1-3):169-72. [Article]
- Proksch E, de Bony R, Trapp S, Boudon S: Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080/09546634.2017.1325310. Epub 2017 May 14. [Article]
- Biro K, Thaci D, Ochsendorf FR, Kaufmann R, Boehncke WH: Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 2003 Aug;49(2):80-4. [Article]
- DRUGS.COM [Link]
- Webmd [Link]
- Pubchem [Link]
- ChemIDplus [Link]
- BASG Product Information: Dolobene (DMSO/heparin sodium/dexpanthenol) topical gel [Link]
- External Links
- KEGG Drug
- D00193
- KEGG Compound
- C05944
- PubChem Compound
- 131204
- PubChem Substance
- 347827835
- ChemSpider
- 115991
- 22701
- ChEMBL
- CHEMBL1200979
- ZINC
- ZINC000001530303
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Panthenol
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Basic Science Cell Proliferation / Gene Expression / Promotion of wound healing 1 4 Completed Treatment Erythemas / Skin Recovery 1 4 Completed Treatment Promotion of wound healing 1 4 Completed Treatment Skin Recovery 2 4 Recruiting Treatment Acute Kidney Injury (AKI) 1 3 Completed Supportive Care Photodamaged Skin 1 3 Completed Treatment Appetite; Lack or Loss, Nonorganic Origin 1 3 Completed Treatment Breast Cancer 1 3 Completed Treatment HbA1c Level / Plasma Homocysteine 1 3 Completed Treatment Hydatidiform Moles 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule; liquid Oral Syrup Oral Liquid Topical Ointment Topical 50 mg/1g Solution Solution 500 mg Tablet, coated Elixir Oral Powder, for solution Intramuscular; Intravenous Powder, for solution Intravenous Injection, solution 500 MG/2ML Tablet 100 MG Ointment Cream Topical Ointment Topical Lozenge 100 mg Ointment Nasal; Ophthalmic Solution Intramuscular; Intravenous; Subcutaneous 500 mg/2ml Ointment Nasal; Ophthalmic 50 mg/g Solution Oral 50 mg/g Spray Topical Ointment 50 mg/g Injection, powder, for solution Intramuscular; Intravenous Injection, powder, for solution Parenteral Injection, powder, for solution Intravenous Gel Ophthalmic Gel Ophthalmic 50 mg/g Gel Ophthalmic 120 mg/0.6mL Gel Ophthalmic 30 mg/0.6mL Gel Ophthalmic 60 mg/0.6mL Solution / drops; suspension / drops Ophthalmic 50 mg/mL Solution / drops; suspension / drops Ophthalmic 30 mg/0.6mL Solution / drops; suspension / drops Ophthalmic 60 mg/0.6mL Gel Topical Lozenge Oral Ointment Topical 5 % Injection, solution Intramuscular; Intravenous 250 mg/1mL Cream Cutaneous Cream Topical 50 mg/g Solution / drops; suspension / drops Ophthalmic Liquid Oral Gel Topical 0.5 g/100mL Liquid Intramuscular; Intravenous Ointment Topical Injection Intramuscular Injection, solution, concentrate; kit Intravenous Injection, powder, lyophilized, for solution Intravenous Kit Intravenous Solution; spray Nasal 50 mg/1mL Spray Nasal 10 mg/1ml Solution Intravenous Liquid Intravenous Solution / drops Oral Spray Nasal 50 mg/ml Shampoo Topical Powder, for solution Oral Solution Intramuscular; Intravenous Solution Buccal; Oropharyngeal Gel Buccal; Oral Solution / drops; suspension / drops Ophthalmic 50 mg Injection, solution Intramuscular; Intravenous 500 mg Cream 5 % Cream Topical Ointment 5 % Solution Oral 5 % Ointment Ophthalmic 5 g Cream Topical 100 g Cream Topical 20 g Cream Topical 50 g Cream Nasal 50 mg/g Cream Topical 5 G/100G Cream Topical 5 % Injection, solution Intramuscular; Intravenous; Subcutaneous 500 mg Cream Injection, solution; kit Intravenous Injection, solution Intravenous Solution Oral Patch Topical Liquid Topical 0.001 g/1mL Syrup Solution / drops Ophthalmic Solution / drops Ophthalmic Liquid; tablet Oral Injection, powder, for solution Intravenous 100 mg Liquid Topical 0.0005 g/1mL Injection Intramuscular; Intravenous Injection Intravenous Injection, solution Intramuscular; Intravenous Spray Nasal Spray, metered Nasal Liquid Topical 0.2 g/100g Solution; spray Nasal - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 121.0 mg/mL ALOGPS logP -1 ALOGPS logP -1.7 Chemaxon logS -0.23 ALOGPS pKa (Strongest Acidic) 12.69 Chemaxon pKa (Strongest Basic) -2.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 89.79 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 51.88 m3·mol-1 Chemaxon Polarizability 21.87 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key GC-MS Spectrum - GC-MS (4 TMS) GC-MS splash10-0f8a-1921000000-f1d6cd175435f0634e26 GC-MS Spectrum - GC-MS (3 TMS) GC-MS splash10-0ar9-0940000000-60184a3322815ca33b8c Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at November 30, 2015 19:10 / Updated at May 29, 2021 18:14