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Ornidazole
go.drugbank.com/drugs/DB13026InvestigationalOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
Mixtures: ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADET, SIPROFORTE 500 MG/ 500 MG FILM TABLET , 20 ADETCategories: Heterocyclic Compounds, 1-Ring, Genito Urinary System and Sex HormonesCimetidine
go.drugbank.com/drugs/DB00501ApprovedInvestigationalIt also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. … A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions.
Synonyms: 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine, N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidineInternational brands: Tagamet HB 200Methadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalMethadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. … [A185888,A185891,A185897] Compared with [morphine], the gold standard reference opioid, methadone also acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: 6-Dimethylamino-4,4-diphenyl-3-heptanoneTenofovir alafenamide
go.drugbank.com/drugs/DB09299ApprovedInvestigational[A178327] Tenofovir alafenamide is indicated to treat chronic hepatitis B,[L6241] treat HIV-1,[L4388,L6277,L6280,L6283] and prevent HIV-1 infections. … [L4388,L9010] Tenofovir alafenamide was developed by Gilead Sciences Inc and granted FDA approval on 5 November 2015.[L6271]
Mixtures: BİKTARVY 50 MG / 200 MG / 25 MG FİLM KAPLI TABLET, 30 TABLET, BİKTARVY 50 MG / 200 MG / 25 MG FİLM KAPLI TABLET, 90 TABLETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesEntacapone
go.drugbank.com/drugs/DB00494ApprovedInvestigationalEntacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. … of levodopa and a decarboxylase inhibitor.
Mixtures: STALEVO ® COMPRIMIDOCON CUBIERTA PELICULAR50 MG. 12.5MG Y 200MG, LEVO C/E BETA200/50/200Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsHydroxyurea
go.drugbank.com/drugs/DB01005ApprovedInvestigational[A262596] It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. … Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: N-Hydroxyurea, N-CarbamoylhydroxylamineMaprotiline
go.drugbank.com/drugs/DB00934ApprovedMaprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: MAPROTILIN-NEURAX 50 MG, Ludiomil 50 mg - FilmtablettenGlipizide
go.drugbank.com/drugs/DB01067ApprovedInvestigational®. … According to the 2018 Clinical Practice Guidelines by Diabetes Canada, sulfonylurea drugs are considered a second-line glucose-lowering therapy following metformin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesSynonyms: 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea, N-{4-[β-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylureaPrednisone
go.drugbank.com/drugs/DB00635ApprovedInvestigationalVet approvedA synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.
Categories: Sex Hormones and Insulins, Cytochrome P-450 SubstratesSynonyms: 1, 2-DehydrocortisoneOlmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigationalangiotensin I to angiotensin II through inhibition of the ACE enzyme. … ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing afterload, increasing cardiac output and preventing ventricular hypertrophy and remodelling.
Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid, 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acidMixtures: SEVIKAR HCT 40 mg/5 mg/25 mg Filmtabletten, Amelior plus HCT 40 mg/5 mg/25 mg Filmtabletten