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Displaying results 6101 - 6110 of 7895 in total
  1. Drug

    Smilagenin

    go.drugbank.com/drugs/DB05450
    Investigational

    P58 therefore provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. … Smilagenin is a novel non-peptide, orally bioavailable neurotrophic factor inducer that readily reverses free radical neurotoxicity produced by 1-ethyl-4- phenylpyridium (MPP+) in dopaminergic neurones

  2. Drug

    KW-7158

    go.drugbank.com/drugs/DB05498
    Experimental

    KW-7158 is a tricyclic compound with a non-cholingergic mechanism of action for the treatment of "urinary urgency," "frequent urination" and "urinary incontinence" associated with bladder overactivity … The therapeutic effects of KW-7158 in overactive bladder may be due to the activation of A-type K(+) channels which regulate afferent neuron excitability and firing properties in the dorsal root ganglion

  3. Drug

    Teverelix

    go.drugbank.com/drugs/DB05624
    Investigational

    A synthetic decapeptide, water-soluble Gonadotropin-releasing hormone antagonist. It has reached phase II clinical trials.

  4. Drug

    OP-145

    go.drugbank.com/drugs/DB05672
    Experimental

    OP-145 is a synthetic antimicrobial peptide developed from human cathelicidin LL-37.

  5. Drug

    FX06

    go.drugbank.com/drugs/DB05685
    Investigational

    FX06 is a naturally occurring peptide derived from the neo-N-terminus of fibrin (Bbeta(15-42)). It prevents leukocyte migration through the gap junctions of endothelial cells.

  6. Drug

    Sinefungin

    go.drugbank.com/drugs/DB01910
    Experimental

    Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar.

  7. Drug

    2,2':6',2''-Terpyridine Platinum(Ii)

    go.drugbank.com/drugs/DB01912
    Experimental

    2,2':6',2''-terpyridine Platinum(Ii) is a solid. Known drug targets of 2,2':6',2''-Terpyridine Platinum(Ii) include truncated transposase and autolysin.

  8. Drug

    Guanosine-5'-Monophosphate

    go.drugbank.com/drugs/DB01972
    Experimental

    A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. [PubChem]

  9. Drug

    Aminooxyacetic acid

    go.drugbank.com/drugs/DB02079
    Experimental

    A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]

  10. Drug

    Phosphoaminophosphonic acid guanylate ester

    go.drugbank.com/drugs/DB02082
    Experimental

    The nucleotide is a potent stimulator of adenylate cyclase. … A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+.