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Displaying results 6211 - 6220 of 7017 in total
  1. Drug

    Insulin-like growth factor II

    go.drugbank.com/drugs/DB14472
    Investigational

    It is believed to be a major fetal growth factor in contrast to insulin-like growth factor I, which is a major growth factor in adults. … The insulin-like growth factor II is a well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood.

  2. Drug

    Cilansetron

    go.drugbank.com/drugs/DB04885
    Experimental

    Cilansetron is a 5HT-3 antagonist made by Solvay Pharmaceuticals that is currently under trial phase in the EU and US.

  3. Drug

    Amodiaquine

    go.drugbank.com/drugs/DB00613
    ApprovedInvestigational

    A 4-aminoquinoquinoline compound with anti-inflammatory properties.

  4. Drug

    TST10088

    go.drugbank.com/drugs/DB05151
    Experimental

    TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating proteins. … These molecules efficiently kill cells by activating preprogrammed death pathways known as apoptosis.

  5. Drug

    PX-12

    go.drugbank.com/drugs/DB05448
    Investigational

    Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced … PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits

  6. Drug

    RUTI® Vaccine

    go.drugbank.com/drugs/DB15853
    Investigational

    Much like the BCG vaccine, the RUTI® vaccine is also being tested as a prophylactic for SARS-CoV2. … The vaccine has demonstrated a reasonable safety profile and potent stimulation of the immune response against tuberculosis.

  7. Drug

    Fulzerasib

    go.drugbank.com/drugs/DB21609
    Investigational

    Fulzerasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Fulzerasib is a Ras protein inhibitor. … Fulzerasib has a monoisotopic molecular weight of 630.22 Da.

  8. Drug

    Rasburicase

    go.drugbank.com/drugs/DB00049
    ApprovedInvestigational

    Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified <i>Saccharomyces cerevisiae</i> strain. … The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_.

  9. Drug

    Siagoside

    go.drugbank.com/drugs/DB12351
    Investigational

    It is a naturally occurring substance in the nerve cell’s membrane that is thought to play a role in cell growth, development, and repair. … Treatment results in a 52% decrease in mortality 48 hours after the induction of ischemia in gerbils by permanent unilateral ligation of the common carotid artery.

  10. Drug

    XL784

    go.drugbank.com/drugs/DB04991
    Investigational

    XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. … It is being developed by Exelixis, Inc.