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Displaying results 6271 - 6280 of 10000 in total
  1. Drug

    Deoxyribonuclease I

    go.drugbank.com/drugs/DB16523
    Investigational

    Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723]. It is normally found in saliva, urine, pancreatic secretions, and blood[A227723]. … Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for airway obstruction, abnormal viscoelastic properties of the sputum, and recurrent exacerbations of respiratory

    Synonyms: DNase I, Deoxyribonuclease ICategories: Deoxyribonuclease I, antagonists & inhibitors
  2. Drug

    Inositol 1,3-bisphosphate

    go.drugbank.com/drugs/DB02942
    Experimental

    The compound corresponds to the soluble headgroup of phosphatidylinositol 3-phosphate (PtdIns(3)P), an endosomal signaling lipid recognized by FYVE domains, and it has been used as a ligand in structural … Inositol 1,3-bisphosphate is a phosphorylated myo-inositol derivative and small molecule metabolite in which phosphate groups occupy the 1 and 3 positions of the inositol ring.

  3. Drug

    Poloxalene

    go.drugbank.com/drugs/DB11451
    InvestigationalVet approved

    Ethylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. … These are compounds containing a cyclic ether with three ring atoms (one oxygen and two carbon atoms).

    Categories: Compounds used in a research, industrial, or household setting
  4. Drug

    Eptotermin alfa

    go.drugbank.com/drugs/DB11631
    ApprovedWithdrawn

    Eptotermin alfa is an ingredient in the EMA-withdrawn product Osigraft. … A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.

    Synonyms: BMP-7, OP-1
  5. Drug

    ONO-2952

    go.drugbank.com/drugs/DB14802
    Investigational

    ONO-2952 is under investigation in clinical trial NCT01887002 (Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable … Bowel Syndrome (IBS-D)).

  6. Drug

    Pucotenlimab

    go.drugbank.com/drugs/DB17552
    ApprovedInvestigational

    Pucotenlimab is a recombinant humanized anti-PD-1 monoclonal antibody. It received its first global approval in China in July 2022 for the treatment of solid tumours. … [A257296] It is being investigated in other cancers.

    Synonyms: Humanized pd-1 blocking antibody hx-008, Immunoglobulin g4 (252-theronine,306-proline,432-alanine), anti-(human programmed cell death 1) (human-mus musculus monoclonal hx008 .gamma.4-chain), disulfide with human-mus musculus monoclonal hx008
  7. Drug

    P-113D

    go.drugbank.com/drugs/DB04987
    Experimental

    It is being pursued as a potential treatment for cystic fibrosis by Demegen, Inc. … P-113D is a novel 12 amino-acid antimicrobial peptide drug derived from histatins, which are compounds found naturally in human saliva.

    Synonyms: D-PEPTIDE OF THE SEQUENCE AKRHHGYKRKFH - NH2
  8. Drug

    Nitenpyram

    go.drugbank.com/drugs/DB11438
    ExperimentalVet approved

    It is a neonicotinoid, a neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of insects, causing rapid death. … Nitenpyram is an insecticide used in agriculture and veterinary medicine to kill external parasites of pets.

    Synonyms: (E)-nitenpyram, (1E)-N-((6-chloro-3-pyridinyl)methyl)-N-ethyl-N'-methyl-2-nitro-1,1-ethenediamineCategories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household setting
  9. Drug

    Nitrocefin

    go.drugbank.com/drugs/DB11592
    Experimental

    Nitrocefin is a chromogenic cephalosporin substrate used to detect the presence of beta-lactamase enzymes, an important mediator of bacterial antibiotic resistance. … While other detection methods exist, such as PCR, nitrocefin allows for rapid detection using few materials and inexpensive equipment.

    Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household setting
  10. Drug

    SR-9011

    go.drugbank.com/drugs/DB14014
    Experimental

    SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues … SR-9011 is a REV-ERB agonist.

    Synonyms: 1-Pyrrolidinecarboxamide, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-n-pentyl-Categories: Heterocyclic Compounds, 1-Ring