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Alemtuzumab
go.drugbank.com/drugs/DB00087ApprovedInvestigational[L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic lymphocytic leukemia (B-CLL). … The dose of alemtuzumab used for B-CLL is much higher than that for MS, and also at more frequent dosing.[L43397, L30335]
Synonyms: Campath 1-HProducts: MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP), MABCAMPATH ® 30 MG/MLDoripenem
go.drugbank.com/drugs/DB06211ApprovedWithdrawnDoripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. … , resulting in a premature termination of the trial.
Categories: Heterocyclic Compounds, 2-RingProducts: DOREXTRA® DORIPENEM 500 MG, REDIDOR 500 MG /VIALAbrocitinib
go.drugbank.com/drugs/DB14973ApprovedInvestigationalAbrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). … [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases,
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: CIBINQO® 50 MG, CIBINQO® 200 MGOxygen
go.drugbank.com/drugs/DB09140ApprovedInvestigationalVet approvedOxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. … Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in
Mixtures: Donopa 50%/50% v/v Gas zur medizinischen Anwendung, druckverdichtet, KALINOX 50 %/ 50 % Gas zur medizinischen Anwendung, druckverdichtetProducts: Oxygen/Helium 50/50, Oxygen Size MLabetalol
go.drugbank.com/drugs/DB00598ApprovedInvestigationalLabetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. … [L7727,L7730] Labetalol was granted FDA approval on 1 August 1984.[L7724]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide, 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcoholAluminum hydroxide
go.drugbank.com/drugs/DB06723ApprovedInvestigationalIt is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin.
Mixtures: DERIVERIN MERHEM, 25 G, ALMA SUSPANSİYON, 200 MLProducts: ALU-TAB TABLET 600 MG, ALU-TAB TABLET 600 mgAntithrombin III human
go.drugbank.com/drugs/DB11598ApprovedInvestigationalA plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Synonyms: Heparin cofactor BProducts: Antithrombin III "Takeda" 50 I.E./ml Pulver und Lösungsmittel zur Herstellung einer Injektionslösung, ANBİNEX 1000 IU/20 ML IV İNFÜZYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON VE ÇÖZÜCÜSÜMepivacaine
go.drugbank.com/drugs/DB00961ApprovedInvestigationalVet approvedMepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168) … A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia.
Mixtures: MEPISEAL-E, Scandonest 2% LCategories: Heterocyclic Compounds, 1-RingAceclofenac
go.drugbank.com/drugs/DB06736ApprovedIt is a more commonly prescribed drug in Europe. … It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies [A19667, A19668, A19670].
Mixtures: ZERODOL PCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesRosuvastatin
go.drugbank.com/drugs/DB01098ApprovedInvestigationalMore specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid and is … [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular
Mixtures: RosuASS 20 mg/100 mg Hartkapseln, ASELIP 20/100 MG EFERVESAN TABLET, 28 ADETCategories: Genito Urinary System and Sex Hormones, Cytochrome P-450 Substrates