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Isosorbide dinitrate
go.drugbank.com/drugs/DB00883ApprovedInvestigationalA vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Categories: Vasodilators Used in Cardiac DiseasesProducts: NOBENITRAT 10 MG TABLET, 20 ADET, NITROFIX 10 MG TRANSMUKOZAL TABLET, 20 ADETDydrogesterone
go.drugbank.com/drugs/DB00378ApprovedInvestigationalWithdrawnUnlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
Synonyms: 10α-Isopregnenone, (9β,10α)-pregna-4,6-diene-3,20-dioneMixtures: Femoston conti 1 mg/5 mg Filmtabletten, Femoston 2/10 TabletCyclosporine
go.drugbank.com/drugs/DB00091ApprovedInvestigationalVet approved[A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Products: Vanquoral 10 mg Weichkapseln, Sandimmun Neoral 10 mg - KapselnMagaldrate
go.drugbank.com/drugs/DB08938ApprovedInvestigationalWithdrawnMagaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
Mixtures: ASIPODAN PLUS FORTE ÇIĞNEME TABLETI, 20 ADET, ASIDOPAN PLUS 200 ML SUSPANSIYONProducts: RIOPAN 80 MG/ML JEL SÜSPANSİYON, MAGALDRATO SPECIAL PRODUCT'S LINEFlubendazole
go.drugbank.com/drugs/DB08974ApprovedInvestigationalWithdrawnFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester, methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamateRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigational[A245393] Roxadustat was first approved by the European Commission in August 2021.[L40323] … Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease.
Categories: Heterocyclic Compounds, 2-RingProducts: Ernevod 20 mg Film Kaplı Tablet (12 adet), EVRENZO 20 MG FİLM KAPLI TABLET, 12 ADETAstemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnAstemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. … It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazoleMavacamten
go.drugbank.com/drugs/DB14921ApprovedInvestigationalIt received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. … [A248440] Mavacamten was also approved by Health Canada in October 2022 and by EMA in July 2023 for the same indication.[L44106,L47471]
Synonyms: 6-(((1S)-1-Phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 tetrahydropyrimidine-2,4-dioneCategories: Heterocyclic Compounds, 1-RingPlerixafor
go.drugbank.com/drugs/DB06809ApprovedInvestigational[A7117] Compared to placebo with G-CSF, the plerixafor and G-CSF mobilization regimen has a higher probability of achieving the optimal CD34+ cell target for tandem transplantation in fewer apheresis procedures … [A7118,L45678] As an inhibitor of CXCR4, plerixafor blocks the binding of its ligand, stromal cell-derived factor-1-alpha (SDF-1α).
Products: AUROPLERISTEM 20 MG/ML, Mozobil 20 mg/ml solution for injectionApixaban
go.drugbank.com/drugs/DB06605ApprovedInvestigationalApixaban was approved by the FDA on December 28, 2012[L6043]. … Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic
Mixtures: ELIQUIS 30-Day Starter Pack, ELIQUIS 30-Day Starter PackCategories: Heterocyclic Compounds, 1-Ring