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Displaying results 641 - 650 of 661 in total
  1. Drug

    Valsartan

    go.drugbank.com/drugs/DB00177
    ApprovedInvestigational

    [A174124,A173869] Valsartan was initially approved in 1996 in Europe for the treatment of hypertension in adults. Shortly after, in 1997, this drug was approved in the United States.

    Mixtures: VALSACOR COMP 160/25MG, VALSACOR COMP 160/25MG
  2. Target

    Tumor necrosis factor ligand superfamily member 13

    go.drugbank.com/bio_entities/BE0010394
    TargetHumans

    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes

    Synonyms: TNF- and APOL-related leukocyte expressed ligand 2
  3. Drug

    Upadacitinib

    go.drugbank.com/drugs/DB15091
    ApprovedInvestigational

    [L10896] In December 2019, it was additionally approved by the European Commission and Health Canada.[L10899,L42540] Upadacitinib is marketed under the brand name RINVOQ for oral administration.

  4. Target

    Ephrin type-B receptor 1

    go.drugbank.com/bio_entities/BE0009441
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the rec...

    Synonyms: Neuronally-expressed EPH-related tyrosine kinase
  5. Drug

    Natural Killer Cell

    go.drugbank.com/drugs/DB15721
    Investigational

    NK Cells express features of innate immune responses, and respond to all molecules that appear to be foreign to the body. … These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral blood.

  6. Target

    Tumor necrosis factor ligand superfamily member 13B

    go.drugbank.com/bio_entities/BE0000999
    TargetHumans

    Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humora...

    Synonyms: TNF- and APOL-related leukocyte expressed ligand 1
  7. Target

    Suppressor of tumorigenicity 14 protein

    go.drugbank.com/bio_entities/BE0001656
    TargetHumans

    Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin ...

    Synonyms: Tumor-associated differentially-expressed gene 15 protein
  8. Target

    Retinol dehydrogenase 11

    go.drugbank.com/bio_entities/BE0002321
    TargetHumans

    Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12036956, PubMed:12226107, PubMed:29410696). Exhibits a low redu...

    Synonyms: HCV core-binding protein HCBP12
  9. Drug

    Human Umbilical Cord Mesenchymal Stem Cells

    go.drugbank.com/drugs/DB15726
    Investigational

    These cells express low levels of major histo-compability complex (MHC) class I, and generally lack MHC class II and its co-stimulatory ligands like CD40, CD80, and CD86.

  10. Drug

    Midazolam

    go.drugbank.com/drugs/DB00683
    ApprovedIllicitInvestigational

    Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in th...