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3-oxo-5-alpha-steroid 4-dehydrogenase
go.drugbank.com/bio_entities/BE0004887EnzymeTargetHumansCatalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 2, 3-oxo-5-alpha-steroid 4-dehydrogenase 1Synonyms: 3-oxo-5-alpha-steroid 4-dehydrogenase 3, S5AR 2Miglitol
go.drugbank.com/drugs/DB00491ApprovedIt is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into … Miglitol should be taken at the start of a meal for maximal effect and the effect will depend on the amount of poly and oligosaccharides in the diet.
Categories: Heterocyclic Compounds, 1-RingProducts: MIOL 25 MG TABLET ,100 TABLET, MIGLITEC 25 MG TABLET, 100 ADETActin-related protein 2/3 complex subunit 3
go.drugbank.com/bio_entities/BE0004253TargetHumansThe Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). … Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
Polypeptides: Actin-related protein 2/3 complex subunit 3Synonyms: Arp2/3 complex 21 kDa subunit3-methyl-2-oxobutanoate hydroxymethyltransferase
go.drugbank.com/bio_entities/BE0001744TargetEscherichia coli (strain K12)Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Polypeptides: 3-methyl-2-oxobutanoate hydroxymethyltransferaseFunction: 3-methyl-2-oxobutanoate hydroxymethyltransferase activityPlutavimab
go.drugbank.com/drugs/DB18856InvestigationalPlutavimab is under investigation in clinical trial NCT04900428 (Study to Evaluate a Single Intranasal Dose of STI-2099 (COVI-DROPS™) in Outpatient Adults With COVID-19 (UK)).
Synonyms: Immunoglobulin g1 (234-alanine,235-alanine), anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein receptor-binding domain) (human monoclonal sti-2020 .gamma.1-chain), disulfide with, Covi-amg2-dehydro-3-deoxyphosphooctonate aldolase
go.drugbank.com/bio_entities/BE0001253TargetAquifex aeolicus (strain VF5)Polypeptides: 2-dehydro-3-deoxyphosphooctonate aldolaseSynonyms: Phospho-2-dehydro-3-deoxyoctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthaseAnagrelide
go.drugbank.com/drugs/DB00261ApprovedInvestigationalAnagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. … [A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g. [busulfan], [hydroxyurea]) and may be better tolerated.[A214274]
Categories: Heterocyclic Compounds, 2-Ring, Phosphodiesterase 3 InhibitorsProducts: ANAGRELID RATIO 1 MG, Anagrelid Nordic 1 mg TablettenTrabectedin
go.drugbank.com/drugs/DB05109ApprovedInvestigationalTrabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. … Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexProducts: Yolisar 1 mg I.V. İnfüzyonluk Çözelti Hazırlamada Kullanılacak Konsantre İçin Toz, 1 ADET, YONDELIS 1 MG IV KONSANTRE INFUZYONLUK COZELTI ICIN TOZDiacerein
go.drugbank.com/drugs/DB11994ApprovedInvestigationalWithdrawnDiacerein is a prodrug which is metabolized to rhein. … Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsProducts: ARTRIDOX®50 MG CAPSULAS, ARTRO - M CAPSULASRilmenidine
go.drugbank.com/drugs/DB11738ApprovedWithdrawnRilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.
Categories: Adrenergic alpha-2 Receptor Agonists, Heterocyclic Compounds, 1-RingProducts: HYPERIUM 1 MG TABLET, 30 ADET, Iterium 1 mg - Tabletten