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Displaying results 6581 - 6590 of 10000 in total
  1. Drug

    Tafluprost

    go.drugbank.com/drugs/DB08819
    Approved

    Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012. … A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

    Mixtures: TAPCOM-S ophthalmic solution 15 micrograms/ml + 5 mg/ml, solution in single-dose container, Taptiqom 15 Mikrogramm/ml + 5 mg/ml Augentropfen, Lösung im EinzeldosisbehältnisProducts: SAFLUTAN®, TAFLOTAN-S OPHTHALMIC SOLUTION 0.0015%
  2. Drug

    Granaticin B

    go.drugbank.com/drugs/DB17273
    Investigational

    Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 1-RingSynonyms: 8,11-ethanofuro(2,3-e)naphtho(2,3-c:6,7-c')dipyran-2,6,13(9h)-trione, 3,3a,5,8,11,13b-hexahydro-7,8,12-trihydroxy-5,9-dimethyl-15-(((2s,5s,6s)-tetrahydro-5-hydroxy-6-methyl-2h-pyran-2-yl)oxy)-, (3as,5s, Granaticin B
  3. Drug

    Mifepristone

    go.drugbank.com/drugs/DB00834
    ApprovedInvestigational

    The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials). … Mifepristone is a progestational and glucocorticoid hormone antagonist.

    Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MG
  4. Drug

    Maraviroc

    go.drugbank.com/drugs/DB04835
    ApprovedInvestigational

    Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: CELSENTRI® 150 MG, CELSENTRI® 300 MG
  5. Target

    Actin-related protein 2/3 complex subunit 3

    go.drugbank.com/bio_entities/BE0004253
    TargetHumans

    The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). … Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).

    Polypeptides: Actin-related protein 2/3 complex subunit 3Synonyms: Arp2/3 complex 21 kDa subunit
  6. Target

    3-methyl-2-oxobutanoate hydroxymethyltransferase

    go.drugbank.com/bio_entities/BE0001744
    TargetEscherichia coli (strain K12)

    Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

    Polypeptides: 3-methyl-2-oxobutanoate hydroxymethyltransferaseFunction: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
  7. Drug

    Vericiguat

    go.drugbank.com/drugs/DB15456
    ApprovedInvestigational

    [A227458,A227488] Cyclic GMP acts as a second messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and these diverse cellular effects have implicated … [A227458] As a direct stimulator of sGC, vericiguat mitigates the need for a functional NO-sGC-cGMP axis and thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC

    Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: VERQUVO 5 MG FİLM KAPLI TABLET , 28 ADET, VERQUVO 5 MG FİLM KAPLI TABLET , 14 ADET
  8. Drug

    Trabectedin

    go.drugbank.com/drugs/DB05109
    ApprovedInvestigational

    Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. … Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically.

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexProducts: Yolisar 1 mg I.V. İnfüzyonluk Çözelti Hazırlamada Kullanılacak Konsantre İçin Toz, 1 ADET, YONDELIS 1 MG IV KONSANTRE INFUZYONLUK COZELTI ICIN TOZ
  9. Drug

    Danazol

    go.drugbank.com/drugs/DB01406
    ApprovedInvestigational

    A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: CIPLADANOGEN® 200 MG CAPSULAS, DANAZOL 100 MG
  10. Target

    2-dehydro-3-deoxyphosphooctonate aldolase

    go.drugbank.com/bio_entities/BE0001253
    TargetAquifex aeolicus (strain VF5)

    Polypeptides: 2-dehydro-3-deoxyphosphooctonate aldolaseSynonyms: Phospho-2-dehydro-3-deoxyoctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase