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Exemestane
go.drugbank.com/drugs/DB00990ApprovedInvestigationalExemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 6-methyleneandrosta-1,4-diene-3,17-dioneAgomelatine
go.drugbank.com/drugs/DB06594ApprovedInvestigationalAgomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. … The Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization on 27 July 2006. The major concern was that efficacy had not been sufficiently shown.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: VALDOXAN® 25 MG, ALODIL®25 MGTABLETARECUBIERTAVilazodone
go.drugbank.com/drugs/DB06684ApprovedInvestigationalVilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. … Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: ZİLADONE 20 MG FİLM KAPLI TABLET, 30 ADET, ZİLADONE 40 MG FİLM KAPLI TABLET, 30 ADETSelinexor
go.drugbank.com/drugs/DB11942ApprovedInvestigational[L7123] Selinexor was also granted accelerated approval for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) that have gone through at least 2 lines of … Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Nexpovio 20 mg Film Kaplı Tablet, 8 TABLET, Nexpovio 20 mg Film Kaplı Tablet, 32 TABLETPadimate O
go.drugbank.com/drugs/DB11570ApprovedIt is a structurally-related compound to [DB02362] that absorbs UV-B rays to prevent photodamage. … Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA [L2153].
Synonyms: Padimate O, Padimate-OMixtures: Kiss My Face SPF 18 Lip Balm, Kiss My Face Everyday Moisturizer SPF 15-lotFedratinib
go.drugbank.com/drugs/DB12500ApprovedInvestigationalFedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.
Categories: MATE 2 Inhibitors, MATE 1 InhibitorsProducts: Inrebic 100 mg capsules, Inrebic 100 mg Sert Kapsül, 120 ADETSuvorexant
go.drugbank.com/drugs/DB09034ApprovedInvestigationalSuvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: BELSOMRA® 20 MG, BELSOMRA® 15 MGComplement 3 Glomerulopathy (C3G)
go.drugbank.com/conditions/DBCOND0138498Drugs: PegcetacoplanSynonyms: Complement 3 Glomerulopathy, Complement 3 GlomerulonephritisType 3 Gaucher disease
go.drugbank.com/conditions/DBCOND0020405Synonyms: Type 3 Gaucher disease, Gaucher Disease Type 3Stage 4 gastrointestinal adenocarcinoma
go.drugbank.com/conditions/DBCOND0020929Drugs: FloxuridineSynonyms: Stage 4 gastrointestinal adenocarcinoma