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Neratinib
go.drugbank.com/drugs/DB11828ApprovedInvestigationalNeratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer.
Synonyms: 奈拉替尼Categories: Heterocyclic Compounds, 2-Ring, Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitorsClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawnClofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. … It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids.
Categories: Heterocyclic Compounds, 3-Ring, P-glycoprotein inhibitorsProducts: CLOFZIMIN® 100 MG, Fazim 50 mg CapsuleSelenium
go.drugbank.com/drugs/DB11135ApprovedInvestigationalVet approvedSelenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen
International brands: B-Traxim SeMixtures: Multitol-M, Prenatol-MSpectinomycin
go.drugbank.com/drugs/DB00919ApprovedVet approvedWithdrawnAn antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Categories: Heterocyclic Compounds, 3-Ring, Heterocyclic Compounds, 1-RingProducts: TROBICIN FOR INJECTION 2 g/vial, Spectro 5% w/v Oral SolutionTrimethyllysine
go.drugbank.com/drugs/DB03977ExperimentalSynonyms: (S)-2-amino-6-(trimethylammonio)hexanoic acid, (S)-5-amino-5-carboxy-N,N,N-trimethyl-1-pentanaminiumThymidine monophosphate
go.drugbank.com/drugs/DB01643Investigational5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2'-deoxy-5-methyluridine 5'-(dihydrogen phosphate), 5'-TMPBrentuximab vedotin
go.drugbank.com/drugs/DB08870ApprovedInvestigationalBrentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). … [L1737] The ECHELON-1 study results demonstrated superior efficacy of the drug combined with a chemotherapy regimen compared to the previous standard of care.
Synonyms: Monoclonal antibody SGN-30, Moab, chimeric, SGN-30, to CD30 antigenCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexEnzalutamide
go.drugbank.com/drugs/DB08899ApprovedInvestigational[A252667,A252642] Due to a favorable pharmacological profile, a phase 1 study of enzalutamide was initiated in July 2007. … [L40639] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: XTANDI ® 40 MG, XTANDI® 40 MGAluminum acetate
go.drugbank.com/drugs/DB14518ApprovedInvestigationalMixtures: ZISUAL-C, SPERTI PREPARATION HProducts: ACETATO DE ALUMINIO 15 MG/100 ML SOLUCION TOPICA, ACID MANTLE® N LOCION.Ranolazine
go.drugbank.com/drugs/DB00243ApprovedInvestigational[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] … Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.
Categories: MATE 2 Inhibitors, MATE 1 InhibitorsProducts: RANEXICOR ® 500, RANEXICOR ® 1000