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Displaying results 661 - 670 of 10000 in total
  1. Target

    Succinate receptor 1

    go.drugbank.com/bio_entities/BE0002258
    TargetHumans

    G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, … Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well

    Polypeptides: Succinate receptor 1Synonyms: G protein-coupled receptor 91
  2. Target

    Neuromedin-K receptor

    go.drugbank.com/bio_entities/BE0002371
    TargetHumans

    Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:37391393). … The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K and substance P (PubMed:1312036).

    Polypeptides: Neuromedin-K receptorSynonyms: NK-3 receptor, Neurokinin B receptor
  3. Target

    B2 bradykinin receptor

    go.drugbank.com/bio_entities/BE0003513
    TargetHumans

    Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: B2 bradykinin receptorSynonyms: BK-2 receptor
  4. Target

    Ryanodine receptor 3

    go.drugbank.com/bio_entities/BE0005296
    TransporterTargetHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed:12354756, PubMed:9395096). May...

    Polypeptides: Ryanodine receptor 3Synonyms: Type 3 ryanodine receptor, Brain-type ryanodine receptor
  5. Target

    5HT3 serotonin receptor

    go.drugbank.com/bio_entities/BE0005582
    TargetHumans

    Polypeptides: 5HT3 serotonin receptor
  6. Target

    B1 bradykinin receptor

    go.drugbank.com/bio_entities/BE0005831
    TargetHumans

    This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

    Polypeptides: B1 bradykinin receptorSynonyms: BK-1 receptor
  7. Target

    Melanocortin receptor 5

    go.drugbank.com/bio_entities/BE0009684
    TargetHumans

    Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH (PubMed:8396929). … G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8396929).

    Polypeptides: Melanocortin receptor 5Function: corticotropin receptor activity
  8. Target

    Thyroid hormone receptor

    go.drugbank.com/bio_entities/BE0009811
    TargetHumans and other mammals

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine … Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

    Polypeptides: Thyroid hormone receptor alpha, Thyroid hormone receptor betaSynonyms: Nuclear receptor subfamily 1 group A member 1, Nuclear receptor subfamily 1 group A member 2
  9. Target

    Olfactory receptor 1D2

    go.drugbank.com/bio_entities/BE0013079
    TargetHumans

    Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro.

    Polypeptides: Olfactory receptor 1D2Synonyms: Olfactory receptor 17-4, Olfactory receptor OR17-6
  10. Target

    Relaxin receptor 2

    go.drugbank.com/bio_entities/BE0017729
    TargetHumans

    Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. … May also be a receptor for Leydig insulin-like peptide (INSL3)

    Polypeptides: Relaxin receptor 2Synonyms: Leucine-rich repeat-containing G protein-coupled receptor 8, G protein-coupled receptor 106