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Dextromethorphan
go.drugbank.com/drugs/DB00514ApprovedInvestigationalDextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. … [A215412] Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Synonyms: Dex, D-methorphanMixtures: BENICAL COLD 500 MG/ 30 MG/20 MG FILM KAPLI TABLET, 20 ADET, DAYCOLD-HOT 500/10/15/100 MG SAŞE ,20 SAŞEBosutinib
go.drugbank.com/drugs/DB06616ApprovedInvestigationalBosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive … Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.
Synonyms: 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrileCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsPenicillamine
go.drugbank.com/drugs/DB00859ApprovedInvestigationalPenicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). … It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.
Synonyms: (S)-2-amino-3-mercapto-3-methylbutanoic acid, D-β,β-dimethylcysteineCategories: Compounds used in a research, industrial, or household settingChloral hydrate
go.drugbank.com/drugs/DB01563ApprovedIllicitInvestigationalVet approvedA hypnotic and sedative used in the treatment of insomnia. … The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments.
Products: PMS-CHLORAL HYDRATE SYRUP 500 mg/5 ml, PMS-chloral Hydrate Syrup 100mg/mlClioquinol
go.drugbank.com/drugs/DB04815ApprovedVet approvedWithdrawnClioquinol was withdrawn in 1983 due to neurotoxicity.
Synonyms: 5-Chlor-7-jod-8-hydroxy-chinolin, 5-Chloro-7-iodo-8-quinolinolMixtures: LOCACORTENE VİOFORME 0,2 MG/G+30 MG/G KREM, 15 G, LOCACORTENE VİOFORME 0,2 MG/G+30 MG/G KREM, 30 GCoagulation factor VIIa Recombinant Human
go.drugbank.com/drugs/DB00036ApprovedInvestigationalNovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form. … Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.
Categories: Increased Coagulation Factor X Activity, Increased Coagulation Factor IX ActivityProducts: NOVOSEVEN RT 1 MG (50 KIU) ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, NOVOSEVEN RT 5 MG (250 KIU) ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜIndapamide
go.drugbank.com/drugs/DB00808ApprovedInvestigational[A204155] Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. … [A204134,A204161] Indapamide is characterized by both a methylindoline and a sulfamoyl chlorobenzamide functional group, with the former being largely responsible for the molecule’s lipid solubility
Mixtures: BI PRETERAX ® 5.0 MG, Triplixam 5 mg/1,25 mg/5 mg FilmtablettenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFexofenadine
go.drugbank.com/drugs/DB00950ApprovedInvestigational[L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation … [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.
Synonyms: 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acidMixtures: ALERMED® D, FEXU D® SUSPENSIONCeftizoxime
go.drugbank.com/drugs/DB01332ApprovedWithdrawnA semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. … The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
Synonyms: 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, syn-7-(2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acidCategories: Heterocyclic Compounds, 2-RingNorethisterone
go.drugbank.com/drugs/DB00717ApprovedInvestigational[A10367] Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency,[A188075] and is used on its own or in combination with estrogen derivatives in a variety of applications … Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.
Synonyms: 17-hydroxy-19-nor-17-α-pregn-4-en-20-yn-3-one, 17-β-hydroxy-19-norpregn-4-en-20-yn-3-oneInternational brands: Primolut-N