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Paliperidone
go.drugbank.com/drugs/DB01267ApprovedInvestigationalIt has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. … Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 9-hydroxyrisperidoneSunitinib
go.drugbank.com/drugs/DB01268ApprovedInvestigationalThese include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). … Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic IndexProducts: DOSTINIB® 25MG, DOSTINIB® 50MGArformoterol
go.drugbank.com/drugs/DB01274ApprovedArformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.
Mixtures: AIRBIR 3/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 120 KPS, AIRBIR 3/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 60 KPSCategories: Cytochrome P-450 Substrates, Adrenergic beta-2 Receptor AgonistsHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigationalOriginally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InhibitorsSynonyms: 6-Hydralazine, 1-HydrazinophthalazinePramlintide
go.drugbank.com/drugs/DB01278ApprovedInvestigationalPramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. … It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
Pirbuterol
go.drugbank.com/drugs/DB01291ApprovedWithdrawnPirbuterol is a beta-2 adrenergic bronchodilator. … ,5†-adenosine monophosphate (c-AMP).
Categories: Adrenergic beta-2 Receptor Agonists, Selective Beta 2-adrenergic AgonistsBismuth subsalicylate
go.drugbank.com/drugs/DB01294ApprovedVet approved[L32318] Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, [metronidazole], and [tetracycline]), which is a treatment regimen indicated for the eradication of _H. pylori_ … [A230728] It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that is used to temporarily treat discomforts of the stomach and gastrointestinal tract.
Synonyms: 2-Hydroxy-benzo[1,3,2]dioxabismin-4-oneProducts: BISMUCAR®, BISLAKSO ®Bevantolol
go.drugbank.com/drugs/DB01295InvestigationalBevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. … Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsSynonyms: 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol, 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-olPractolol
go.drugbank.com/drugs/DB01297ApprovedA beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.
Categories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor AntagonistsSynonyms: 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamideSulfacytine
go.drugbank.com/drugs/DB01298ApprovedSulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. … Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase.
Synonyms: 1-ethyl-N-sulfanilylcytosine, 1-ethyl N4-sulfanilylcytosin