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Displaying results 671 - 680 of 7017 in total
  1. Drug

    Cytarabine

    go.drugbank.com/drugs/DB00987
    ApprovedInvestigational

    A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. … Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: Aj-cytarabine, ALDACIT® 500 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE
  2. Drug

    Methotrexate

    go.drugbank.com/drugs/DB00563
    ApprovedInvestigational

    [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division. … Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis.

    Categories: OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: AC-VONDA, METHOTREXAT AC 50MG/2ML
  3. Indication

    Genital Ulcer Disease (GUD)

    go.drugbank.com/conditions/DBCOND0059547
    Drugs: Azithromycin
    Synonyms: Genital Ulcer Disease (GUD)
  4. Drug

    Cimetidine

    go.drugbank.com/drugs/DB00501
    ApprovedInvestigational

    A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. … It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.

    Products: AA-Cimetidine 200mg Tablet
  5. Drug

    alpha-Tocopherol acetate

    go.drugbank.com/drugs/DB14003
    Approved

    At the moment however, there exists a lack of formal data and evidence to support any such additional indications for vitamin E use. … Moreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed [A32451].

    Mixtures: ROROBELL WAWA Gum Care Tooth, Denti Boungiorno Gum Care ToothCategories: Compounds used in a research, industrial, or household setting, Vitamins (Fat Soluble)
  6. Drug

    Budesonide

    go.drugbank.com/drugs/DB01222
    ApprovedInvestigational

    [L10598] It is also available in a combination product with [formoterol].[L10619] … Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.

    Mixtures: SYMBICORT T 320/9UG 60ED, SYMBICORT T 320/9UG 60EDProducts: Mylan-budesonide AQ, Budenase AQ Nasal Spray 64 mcg /dose
  7. Drug

    Tetracycline

    go.drugbank.com/drugs/DB00759
    ApprovedInvestigationalVet approvedWithdrawn

    It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. … Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria.

    Products: Tetracycline 3 percent a First Aid Antibiotic, APT T3X Tetracycline Hydrochloride First Aid Antibiotic
  8. Drug

    Tegaserod

    go.drugbank.com/drugs/DB01079
    ApprovedWithdrawn

    (4)) receptors in smooth muscle cells and in the gastrointestinal wall to facilitate actions like esophageal relaxation, peristaltic gut movement, and natural secretions in the gut, among others. … a lower risk of a cardiovascular event than the broader population.

  9. Drug

    Tocopherol

    go.drugbank.com/drugs/DB11251
    ApprovedInvestigational

    When the carbons at position 5- and 7- are not methylated, they can function as electrophilic centers that can trap reactive oxygen and nitrogen species. … Tocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain.

    Mixtures: Protect Cardio AF, GelCategories: Compounds used in a research, industrial, or household setting, Vitamins (Fat Soluble)
  10. Drug

    Fenproporex

    go.drugbank.com/drugs/DB01550
    ApprovedIllicitWithdrawn

    In 2006 and 2009, the FDA issued warnings that it had been detected in diet pills sold online, and imported from foreign manufacturers. … Fenproporex is an orally active stimulant drug, which was developed in the 1960s. It is used as an appetite suppressant and a treatment for obesity.

    Products: IFA-DIETY A. P.