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Efepoetin alfa
go.drugbank.com/drugs/DB19197InvestigationalEfepoetin alfa is under investigation in clinical trial NCT04155125 (A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient).
Synonyms: Human erythropoietin (epoetin alfa) fused to a hybrid human immunoglobulin (ig), consisting of the fc fragment of the igg4 fused to the hinge and amino-terminus of the igd heavy chain isotype 2, producedClervonafusp alfa
go.drugbank.com/drugs/DB17623InvestigationalSynonyms: Immunoglobulin g1-kappa, cell-penetrating humanized fab fragment targeting the equilibrative nucleoside transporter 2 (ent2), fused with a human lysosomal .alpha.-glucosidase fragment, glycoform alfa, Immunoglobulin g1, (humanized monoclonal 3e10 .gamma.1-chain fab fragment) fusion protein with 67-952-lysosomal .alpha.Corifollitropin alfa
go.drugbank.com/drugs/DB09066ApprovedInvestigationalCorifollitropin alfa is produced by a method known as ‘recombinant DNA technology’. … In July 2014, Merck announced the receipt of a Complete Response Letter (CRL) from the U.S. FDA for its New Drug Application for this drug.
Products: GONAL-F ® 300 UI (22 MCG)/0.5 ML INYECTOR (FOLITROPINA ALFA (R-HFSH)), GONAL-F ® INYECTOR 900 UI (66 MCG)/1.5 MLTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnAs a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: NAVOBAN 5 MG 1 AMPUL, Navoban 5 mg - AmpullenEconazole
go.drugbank.com/drugs/DB01127ApprovedA broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.
Mixtures: Econazole Nitrate 1% / Niacinamide 4%, 071023 Econazole Nitrate 1% / Niacinamide 4%Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-RingDeucravacitinib
go.drugbank.com/drugs/DB16650ApprovedInvestigationalUnlike other Janus kinase 1/2/3 inhibitors that bind to the conserved active domain of these non-receptor tyrosine kinases, deucravacitinib binds to the regulatory domain of TYK2 with high selectivity … Deucravacitinib is a novel oral selective tyrosine kinase 2 (TYK2) inhibitor.
Categories: Tyrosine Kinase 2 Inhibitor, P-glycoprotein substratesProducts: SOTYKTU 6 mg film coated tablets, SOTYKTU® 6MG TABLETAS RECUBIERTAS3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
go.drugbank.com/bio_entities/BE0000051TargetEnzymeHumansA bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. … Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol
Polypeptides: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1Synonyms: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-hydroxysteroid 3-dehydrogenaseTrastuzumab emtansine
go.drugbank.com/drugs/DB05773ApprovedInvestigationalTrastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent … T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-microtubule agent, DM1 (a maytansine derivative)--to produce cell cycle arrest and apoptosis.
Categories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: T-DM1Zotepine
go.drugbank.com/drugs/DB09225ApprovedWithdrawnZotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA.
Categories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 SubstratesProducts: ZOLEPTIL © 50 MG TABLETAS RECUBIERTAS.Sulodexide
go.drugbank.com/drugs/DB06271ApprovedInvestigationalWithdrawnSulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).
Products: ANJIOFLUX 600 LRU 2 ML ENJEKTABL COZELTI ICEREN 10 AMPUL, VESSEL DUE F