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Displaying results 6891 - 6900 of 10000 in total
  1. Target

    Histone deacetylase 4

    go.drugbank.com/bio_entities/BE0003523
    TargetHumans

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation...

    Polypeptides: Histone deacetylase 4
  2. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0004267
    TargetStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseFunction: 4-hydroxyphenylpyruvate dioxygenase activity
  3. Target

    P2X purinoceptor 4

    go.drugbank.com/bio_entities/BE0005793
    TargetHumans

    Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity).

    Polypeptides: P2X purinoceptor 4
  4. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    In the PVN, also interacts with opsin 3/OPN3, which couples to G(i/o) proteins to inhibit MC4R-mediated cAMP signaling, thereby promoting food intake (PubMed:39951488).

    Polypeptides: Melanocortin receptor 4
  5. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway

    Polypeptides: Platelet glycoprotein 4Synonyms: PAS-4
  6. Drug

    Inotuzumab ozogamicin

    go.drugbank.com/drugs/DB05889
    ApprovedInvestigational

    Inotuzumab ozogamicin is an antibody-drug conjugate consisting of a humanized IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin … [L938] A month later, inotuzumab ozogamicin was also approved by the FDA.[L50542]

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesProducts: BESPONSA 1 MG IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ, 1 ADET, BESPONSA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 1MG/VIAL
  7. Drug

    Capsaicin

    go.drugbank.com/drugs/DB06774
    ApprovedInvestigational

    Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. … The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.

    Synonyms: (E)-8-Methyl-N-vanillyl-6-nonenamide, trans-8-Methyl-N-vanillyl-6-nonenamideMixtures: Med O-3 Bio-, Dfs 1.5%/ms 25%/menth 6%/cap 0.025% Pak
  8. Drug

    Calcium Phosphate

    go.drugbank.com/drugs/DB11348
    ApprovedInvestigational

    Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] .

    Mixtures: MULTIVIT M® CAPSULAS, Stom #2Categories: ascorbic acid (vit C) and calcium, Compounds used in a research, industrial, or household setting
  9. Indication

    Poliomyelitis caused by poliovirus type 2

    go.drugbank.com/conditions/DBCOND0093720
    Drugs: Poliovirus type 2 antigen (formaldehyde inactivated)
    Synonyms: Poliomyelitis caused by poliovirus type 2
  10. Indication

    Metastatic Her-2 Positive Gastric Cancer

    go.drugbank.com/conditions/DBCOND0146827
    Drugs: Trastuzumab deruxtecan
    Synonyms: Metastatic Her-2 Positive Gastric Cancer