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Eprodisate
go.drugbank.com/drugs/DB06405InvestigationalEprodisate slows the decline of renal function in AA amyloidosis.
TM5614
go.drugbank.com/drugs/DB16516InvestigationalAn animal study in mice fed a fast-food diet with TM5614 treatment showed improved metabolic measurements and reduced liver steatosis[L31673,L31678]. … Further investigation of this compound is underway, including an exploratry Phase II study for its efficacy and safety for high-risk hospitalized patients with severe COVID-19 pneumonia[L31688].
D-JNKI-1
go.drugbank.com/drugs/DB05660InvestigationalA synthetic, cell permeable peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of both the morphological integrity and physiological function of the organ of Corti during times of ox...
Synonyms: D-JNKI 1 peptideZeranol
go.drugbank.com/drugs/DB11478ExperimentalVet approvedIt is 3-4x more potent as an estrogen agonist than the related compound zearalenone.
Cyclopropane
go.drugbank.com/drugs/DB13984ExperimentalInstead, it turned out to be an excellent anesthetic with very rapid onset and recovery while maintaining stable hemodynamics. Its use was ultimately limited because it was highly explosive.
Methoxy arachidonyl fluorophosphonate
go.drugbank.com/drugs/DB02465ExperimentalMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases.
RP01
go.drugbank.com/drugs/DB05751ExperimentalIt is designed to induce the immune system to produce antibodies that block Immunoglobulin E (IgE), the key mediator of an allergic response.
alpha-Hydroxy glycineamide
go.drugbank.com/drugs/DB06568ExperimentalIt also has an effect on viral gp160 envelope protein. [A31692]
Belnacasan
go.drugbank.com/drugs/DB05507InvestigationalVX-765 is currently under clinical development for the treatment of inflammatory and autoimmune conditions, as it blocks the hypersensitive response to an inflammatory stimulus.