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Displaying results 61 - 70 of 124 in total
  1. Pathway

    Normethadone Action Pathway

    smpdb.ca/view/SMP0126829
    Drug action

    Normethadone is an opioid antitussive used to treat a cough associated with inflamed mucosa. Normethadone binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  2. Pathway

    Nalbuphine Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0126326
    Drug action

    Nalbuphine also prevents the gamma subunit of the mu opioid receptor from inhibiting the N-type calcium channels on the neuron. This allows calcium to enter the neuron and depolarize.

    Drugs: ATP · Nalbuphine · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  3. Pathway

    Nalmefene Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0126315
    Drug action

    Nalmefene also prevents the gamma subunit of the mu opioid receptor from inhibiting the N-type calcium channels on the neuron. This allows calcium to enter the neuron and depolarize.

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  4. Pathway

    Samidorphan Action Pathway

    smpdb.ca/view/SMP0126322
    Drug action

    Samidorphan also prevents the gamma subunit of the mu opioid receptor from inhibiting the N-type calcium channels on the neuron. This allows calcium to enter the neuron and depolarize.

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  5. Pathway

    Dihydrocodeine Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0124998
    Drug action

    Dihydrocodeine is an opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Dihydrocodeine is a semi-synthetic opioid analgesic. Dihydrocod...

    Drugs: ATP · Calcium · Magnesium cation · Dihydrocodeine · Dihydromorphine · Cyclic adenosine monophosphate +3 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  6. Pathway

    Butorphanol Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0126319
    Drug action

    Butorphanol also prevents the gamma subunit of the mu opioid receptor from inhibiting the N-type calcium channels on the neuron. This allows calcium to enter the neuron and depolarize.

    Drugs: ATP · Butorphanol · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  7. Pathway

    Remifentanil Opioid Anasthetic Action Pathway

    smpdb.ca/view/SMP0125022
    Drug action

    Remifentanil is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which acts in the brain, spinal co...

    Drugs: ATP · Remifentanil · Calcium · Magnesium cation · Dihydrocodeine · Cyclic adenosine monophosphate +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  8. Pathway

    Naloxone Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0126328
    Drug action

    Naloxone also prevents the gamma subunit of the mu opioid receptor from inhibiting the N-type calcium channels on the neuron. This allows calcium to enter the neuron and depolarize.

    Drugs: ATP · Naloxone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  9. Pathway

    Piritramide Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0126816
    Drug action

    Piritramide is an opioid analgesic used to treat severe pain. It is under investigation for the treatment of colon cancer and minimal residual disease. Piritramide binds to mu, kappa, and delta opioid receptors on presynaptic neuron memb...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  10. Pathway

    Dihydroetorphine Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0126823
    Drug action

    Dihydroetorphine binds to opioid receptors on presynaptic neuron membranes, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma...

    Drugs: ATP · Calcium · Magnesium cation · Dihydroetorphine · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2