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Activin receptor type-2B
go.drugbank.com/bio_entities/BE0010524TargetHumansActivin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor … Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor.
Polypeptides: Activin receptor type-2BSynonyms: Activin receptor type IIBGalanin receptor type 2
go.drugbank.com/bio_entities/BE0011498TargetHumansThe activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)) … Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231).
Polypeptides: Galanin receptor type 2Function: galanin receptor activitySigma intracellular receptor 2
go.drugbank.com/bio_entities/BE0015084TargetHumansSigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking
Polypeptides: Sigma intracellular receptor 2Synonyms: Sigma2 receptor, Sigma-2 receptorChemerin-like receptor 1
go.drugbank.com/bio_entities/BE0019036TargetHumansReceptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. … Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation
Polypeptides: Chemerin-like receptor 1Synonyms: Chemokine-like receptor 1, G protein-coupled receptor DEZCapsaicin
go.drugbank.com/drugs/DB06774ApprovedInvestigationalThe most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersProducts: Capzasin-P Creme - 0.025%, Capzasin P Arthritis Pain ReliefPalonosetron
go.drugbank.com/drugs/DB00377ApprovedInvestigationalAs of 2008, it is the most recent 5-HT3 antagonist to enter clinical use.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAbiprubart
go.drugbank.com/drugs/DB19333InvestigationalAbiprubart is being evaluated for its efficacy and safety in participants with Sjögren's Disease in clinical trial NCT06531395
Synonyms: 1-441) [VH (Homo sapiens IGHV1-3*01 (83.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.7] (26-33.51-58.97-103)) (1-114)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (115-212), hinge 1-12 S10>P, Immunoglobulin G4-kappa, anti-[Homo sapiens CD40 (TNFRSF5, tumor necrosis factor receptor (TNFR) superfamily member 5, p50)], humanized monoclonal antibodyMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalMoreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsHaloprogin
go.drugbank.com/drugs/DB00793ApprovedWithdrawnThe mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function.
Endothelin receptor type B
go.drugbank.com/bio_entities/BE0000043TargetHumansNon-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Polypeptides: Endothelin receptor type BSynonyms: Endothelin receptor non-selective type