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Toloxatone
go.drugbank.com/drugs/DB09245ExperimentalToloxatone is an antidepressant agent, the first ever use of which was in France, 1984. It acts as a selective and reversible inhibitor of monoamine oxidase-A (MOA) .
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeMephenesin
go.drugbank.com/drugs/DB13583ApprovedWithdrawnMephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression . It first entered use in the 1950s.
Synonyms: 3-(O-METHYLPHENOXY)-1,2-PROPANEDIOL(1S,2R,3S,4R,5R)-2,3,4-trihydroxy-N-octyl-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioamide
go.drugbank.com/drugs/DB08260Experimental(1S,2R,3S,4R,5R)-2,3,4-trihydroxy-N-octyl-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioamide is a solid. This compound belongs to the oxepanes.
Synonyms: (1S,2R,3S,4R,5R)-2,3,4-trihydroxy-N-octyl-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioamideCalcimycin
go.drugbank.com/drugs/DB19408InvestigationalIt binds to and transports calcium and other divalent cations across membranes, disrupts oxidative phosphorylation, and inhibits ATPase in rat liver mitochondria.
Xeruborbactam
go.drugbank.com/drugs/DB21512InvestigationalXeruborbactam is under investigation in clinical trial NCT07104162 (A Study to Investigate Safety and Pharmacokinetics of Intravenous Cefiderocol/Xeruborbactam in Participants With Renal Impairment).
Docirbrutinib
go.drugbank.com/drugs/DB21606InvestigationalDocirbrutinib is under investigation in clinical trial NCT05602363 (AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma).
Tamuzimod
go.drugbank.com/drugs/DB21621InvestigationalTamuzimod is under investigation in clinical trial NCT05156125 (VTX002 Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis).
Zavacorilant
go.drugbank.com/drugs/DB21509InvestigationalThe usage of the INN stem '-corilant' in the name indicates that Zavacorilant is a glucocorticoid receptor antagonist (non-steroidal).
Vabicaserin
go.drugbank.com/drugs/DB12071InvestigationalVabicaserin has been used in trials studying the health services research and treatment of Schizophrenia.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome