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Conivaptan
go.drugbank.com/drugs/DB00872ApprovedIt was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). … Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin).
Products: Vaprisol Dextrose In Plastic ContainerAmmonium lactate
go.drugbank.com/drugs/DB06768ApprovedAmmonium lactate is the ammonium salt of lactic acid.
Mixtures: Ultravate X, Ultravate XSynonyms: Lactic acid ammonium saltMethyldopa
go.drugbank.com/drugs/DB00968ApprovedInvestigational[A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. … [A231784] It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects.
Categories: Antihypertensive Agents Indicated for HypertensionInternational brands: Nu-MedopaPentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigational[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for … [A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold under the trade name TRENTAL by US Pharm Holdings were first approved by the FDA on Aug 30, 1984, but
Categories: Compounds used in a research, industrial, or household setting, Drugs for Obstructive Airway DiseasesInternational brands: Ao Le Ni, An Ruo NingTasonermin
go.drugbank.com/drugs/DB11626ApprovedIt was approved for use by the European Medicines Agency in April of 1999 for use as an adjunt to surgery for the subsequent removal of the tumor and in palliative care for irresectable soft tissue sarcoma … Tasonermin is recombinant soluble form tumor necrosis factor α produced via _Escherichia coli_ cell culture.
Synonyms: Tumor necrosis factor, soluble form, nonglycosylatedIvermectin
go.drugbank.com/drugs/DB00602ApprovedInvestigationalVet approved[L36763,A238929] In addition, the use of aggregate patient data in large-scale meta-analyses (as opposed to individual patient data (IPD)) has been shown to disguise otherwise blatant data errors, such … While studies are still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and the clinical utility of this data remains unclear.
Mixtures: Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbs, Eqvalan Duo Oral Paste for HorseCategories: Compounds used in a research, industrial, or household settingDoxycycline
go.drugbank.com/drugs/DB00254ApprovedInvestigationalVet approved[A174034] Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.[A251730] … Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline].[L42880] It is a second-generation tetracycline that was first discovered in 1967.
International brands: Nu-DoxycyclineCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseZuclopenthixol
go.drugbank.com/drugs/DB01624ApprovedInvestigationalIt is known that zuclopenthixol is metabolized by Cytochrome P450 2D6. Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States. … Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: CLOPIXOL-ACUPHASE INJ 50MG/ML (1ML), Clopixol Depot - Liq Im 200mg/mlThimerosal
go.drugbank.com/drugs/DB11590ApprovedAlthough thimerosal is banned in several countries, it continues to be included as a preservative in some vaccines in the United States and many vaccines in the developing world [L1685]. … Developed in 1927, thimerosal has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines.
Synonyms: [(o-carboxyphenyl)thio]ethylmercury sodium salt, o-(ethylmercurithio)benzoic acid sodium saltCategories: Compounds used in a research, industrial, or household settingCanakinumab
go.drugbank.com/drugs/DB06168ApprovedInvestigationalClinical trials have established the administration of canakinumab every 2 weeks to be safe and effective, offering a considerable advantage over the existing treatment with the human IL-1 receptor antagonist … Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra).
Products: ILARIS 150MG POWDER FOR SOLUTION FOR INJECTION, Ilaris Powder for Solution for Injection 150mg/vial