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Displaying results 731 - 740 of 3729 in total
  1. Target

    Somatostatin receptor type 5

    go.drugbank.com/bio_entities/BE0002147
    TargetHumans

    Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

    Polypeptides: Somatostatin receptor type 5
  2. Target

    Toll-like receptor 4

    go.drugbank.com/bio_entities/BE0002442
    TargetHumans

    Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream … In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86 (PubMed:23880187).

    Polypeptides: Toll-like receptor 4
  3. Target

    Glucose-dependent insulinotropic receptor

    go.drugbank.com/bio_entities/BE0003378
    TargetHumans

    Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. … The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway

    Polypeptides: Glucose-dependent insulinotropic receptorSynonyms: G protein-coupled receptor 119
  4. Target

    Activin receptor type-2A

    go.drugbank.com/bio_entities/BE0003472
    TargetHumans

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. … Receptor for activin A, activin B and inhibin A (PubMed:17911401, PubMed:10652306). Mediates induction of adipogenesis by GDF6 (By similarity)

    Polypeptides: Activin receptor type-2ASynonyms: Activin receptor type IIA
  5. Target

    Leukotriene B4 receptor 2

    go.drugbank.com/bio_entities/BE0003489
    TargetHumans

    Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. … The response is mediated via G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3

    Polypeptides: Leukotriene B4 receptor 2Synonyms: LTB4 receptor JULF2, Leukotriene B4 receptor BLT2
  6. Target

    Nuclear receptor coactivator 2

    go.drugbank.com/bio_entities/BE0003740
    TargetHumans

    Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108).

    Polypeptides: Nuclear receptor coactivator 2Function: aryl hydrocarbon receptor binding
  7. Target

    Thyroid hormone receptor alpha

    go.drugbank.com/bio_entities/BE0003867
    TargetHumans

    Polypeptides: Thyroid hormone receptor alphaSynonyms: Nuclear receptor subfamily 1 group A member 1, Thyroid hormone receptor, alpha isoform 1 variant
  8. Target

    Nuclear receptor coactivator 5

    go.drugbank.com/bio_entities/BE0004057
    TargetHumans

    Nuclear receptor coregulator that can have both coactivator and corepressor functions. … Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2.

    Polypeptides: Nuclear receptor coactivator 5
  9. Target

    receptor protein-tyrosine kinase

    go.drugbank.com/bio_entities/BE0004155
    TargetHumans

    Polypeptides: receptor protein-tyrosine kinase
  10. Target

    Acetylcholine receptor subunit alpha

    go.drugbank.com/bio_entities/BE0004661
    TargetHumans

    Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

    Polypeptides: Acetylcholine receptor subunit alpha