Toll-like receptor 4

BE0002442ProteinHumansTLR4

Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:10835634, PubMed:15809303, PubMed:16622205, PubMed:17292937, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187,... It is acted on by 30 drugs in DrugBank.

Gene name
TLR4
UniProtKB entry
O00206Swiss-Prot
Cellular location
Cell membrane
Residues / weight
839 residues · 95,679 Da
Also known as
hToll

Resolves to

Protein
UniProtO00206UniProt nameTLR4_HUMAN
Gene
HGNCHGNC:11850NCBI Gene7099GeneCardsTLR4
Pharmacology
IUPHAR/GtoPdb1754KEGGhsa:7099
Structure
PDB2Z62PDB2Z63PDB2Z65
Drugs

What you can answer from here — as of September 07, 2019

30DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
30GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
85+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Toll-like receptor 4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In