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Avalglucosidase alfa
go.drugbank.com/drugs/DB16099ApprovedInvestigational[A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. … [L35160] Avalglucosidase alfa was approved by Health Canada on November 15, 2021 for the treatment of patients older than six months of age with late-onset Pompe disease.
Sirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigationalSirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island … [A1320] Sirolimus was first approved by the FDA in 1999 for the prophylaxis of organ rejection in patients aged 13 years and older receiving renal transplants.
Efmoroctocog alfa
go.drugbank.com/drugs/DB11607ApprovedInvestigationalknown biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. … In animal models of haemophilia, efmoroctocog alfa demonstrated an approximately two-fold longer t½ than commercially available rFVIII products [A31551].
Repotrectinib
go.drugbank.com/drugs/DB16826ApprovedInvestigationalThis approval is based on favorable results from the TRIDENT-1 study, where the objective response rate was 79% in TKI-naive patients and 38% in TKI-pretreated patients respectively.[L48741] … [A262061] Although resistance to multiple TKI has been reported, including [crizotinib], [lorlatinib], [taletrectinib], and [entrectinib], there has been no reported case of repotrectinib resistance.
Meclizine
go.drugbank.com/drugs/DB00737ApprovedInvestigational[L6760] Commonly marketed under the brand name Antivert in the U.S., meclizine is available as oral tablets.
Products: Dramamine - NMiglustat
go.drugbank.com/drugs/DB00419ApprovedInvestigationalMiglustat is now the first and only approved therapy for patients with Niemann-Pick disease type C (NP-C).
Synonyms: N-(n-Butyl)deoxynojirimycin, NB-DNJDextromethorphan
go.drugbank.com/drugs/DB00514ApprovedInvestigationalDextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethor...
Mixtures: Brom Tapp DM, Brom/PSE/DM CoughCategories: Uncompetitive N-methyl-D-aspartate Receptor AntagonistInfluenza A virus A/Brisbane/10/2010 (H1N1) antigen (MDCK cell derived, propiolactone inactivated)
go.drugbank.com/drugs/DB10998ApprovedInvestigationalWithdrawnThere are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). … The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses.
Mixtures: Medical Provider Single Use EZ Flu Shot Flucelvax 2014-2015 Kit, Medical Provider Single Use EZ Flu Shot Flucelvax 2015-2016Icatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigational[L49776,L49781] The FDA approval was based on positive results obtained from 3 double-blind, randomized, controlled clinical trials known as FAST 1, 2, and 3, where a median time to almost complete symptom
Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated)
go.drugbank.com/drugs/DB11044ApprovedWithdrawnThere are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). … The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses.
Mixtures: Medical Provider Single Use EZ Flu Shot Afluria 2016-2017, Medical Provider Single Use EZ Flu Shot Fluvirin 2016-2017