This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated)
- DrugBank Accession Number
- DB11044
- Background
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.
There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Vaccines
Inactivated - Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbatacept The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Abatacept. Adalimumab The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Adalimumab. Aldesleukin The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Aldesleukin. Alefacept The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Alefacept. Alemtuzumab The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Alemtuzumab. Altretamine The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Altretamine. Amsacrine The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Amsacrine. Anakinra The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Anakinra. Anifrolumab The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Anifrolumab. Antilymphocyte immunoglobulin (horse) The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) can be decreased when used in combination with Antilymphocyte immunoglobulin (horse). 
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- Not Available
Products
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Name Kind UNII CAS InChI Key Influenza B virus B/Brisbane/60/2008 hemagglutinin antigen (propiolactone inactivated) hemagglutinin 45E2IPU4MG Not Available Not applicable - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-181 (H1N1) antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Seqirus Pty Ltd 2011-07-15 2016-06-17 US 
Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Csl Limited 2011-07-15 2012-06-30 US Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Brisbane/59/2007(H1N1) antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Uruguay/716/2007(H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Csl Limited 2009-07-01 2010-06-30 US Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Csl Limited 2010-07-30 2011-06-30 US Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-181 (H1N1) antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Seqirus Pty Ltd 2011-07-15 2016-06-17 US Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Csl Limited 2011-07-15 2012-06-30 US Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Csl Limited 2010-07-30 2011-06-30 US Afluria Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (7.5 ug/0.25mL) + Influenza A virus A/Brisbane/59/2007(H1N1) antigen (propiolactone inactivated) (7.5 ug/0.25mL) + Influenza A virus A/Uruguay/716/2007(H3N2) antigen (propiolactone inactivated) (7.5 ug/0.25mL) Injection, suspension Intramuscular Csl Limited 2009-07-01 2010-06-30 US Fluvirin Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Catalent Belgium Sa 2017-07-01 2018-06-30 US Fluvirin Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74 (H1N1) antigen (propiolactone inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (propiolactone inactivated) (15 ug/0.5mL) Injection, suspension Intramuscular Seqirus, Inc. 2016-07-01 2017-06-30 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 293LSV29OL
- CAS number
- Not Available
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Flu caused by Influenza 1 4 Completed Prevention Influenza, Human 3 4 Enrolling by Invitation Treatment Infertility 1 4 Recruiting Basic Science Coronavirus Disease 2019 (COVID‑19) / Lymphoma 1 4 Unknown Status Treatment Infertility / Recurrent Miscarriages 1 3 Active Not Recruiting Prevention Coronavirus Disease 2019 (COVID‑19) / Respiratory Syncytial Virus (RSV) 1 3 Completed Prevention Flu caused by Influenza 2 1, 2 Completed Prevention Allergy, Egg / Eligible for Vaccination Against Influenza 1 Not Available Completed Not Available Fetal Malformation / Influenza, Human / Pregnancy 1 Not Available Completed Not Available Inflammatory Bowel Diseases (IBD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, suspension Intramuscular Kit Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at December 01, 2015 20:05 / Updated at June 12, 2020 16:53