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Displaying results 7751 - 7760 of 10000 in total
  1. Target

    cGMP-dependent protein kinase 2

    go.drugbank.com/bio_entities/BE0009526
    TargetHumans

    Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379)...

    Polypeptides: cGMP-dependent protein kinase 2Synonyms: cGK 2
  2. Target

    Interleukin-1 receptor type 2

    go.drugbank.com/bio_entities/BE0009549
    TargetHumans

    Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association w...

    Polypeptides: Interleukin-1 receptor type 2Synonyms: IL-1R-2, IL-1RT-2
  3. Target

    Prostaglandin G/H synthase 2

    go.drugbank.com/bio_entities/BE0009550
    TargetCanis lupus familiaris

    Polypeptides: Prostaglandin G/H synthase 2Synonyms: COX-2, Cyclooxygenase 2
  4. Target

    Metallo-beta-lactamase type 2

    go.drugbank.com/bio_entities/BE0009973
    TargetEnzymeKlebsiella pneumoniae

    Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

    Polypeptides: Metallo-beta-lactamase type 2
  5. Target

    Elongation factor 1-alpha 2

    go.drugbank.com/bio_entities/BE0010196
    TargetHumans

    Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon...

    Polypeptides: Elongation factor 1-alpha 2Synonyms: eEF1A-2, EF-1-alpha-2
  6. Target

    Insulin-like growth factor 2

    go.drugbank.com/bio_entities/BE0010370
    TargetHumans

    The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved i...

    Polypeptides: Insulin-like growth factor 2Synonyms: IGF-2
  7. Target

    Cytokine receptor-like factor 2

    go.drugbank.com/bio_entities/BE0010586
    TargetHumans

    Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in ...

    Polypeptides: Cytokine receptor-like factor 2Synonyms: Cytokine receptor-like 2
  8. Target

    C-terminal-binding protein 2

    go.drugbank.com/bio_entities/BE0013651
    TargetHumans

    Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity)

    Polypeptides: C-terminal-binding protein 2
  9. Target

    Corticotropin-releasing hormone receptor 2

    go.drugbank.com/bio_entities/BE0014244
    TargetHumans

    G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579, PubMed:32004470, PubMed:36335102)....

    Polypeptides: Corticotropin-releasing hormone receptor 2Synonyms: CRFR-2, CRF-R-2
  10. Target

    2-hydroxyacylsphingosine 1-beta-galactosyltransferase

    go.drugbank.com/bio_entities/BE0015078
    EnzymeHumans

    Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed...

    Polypeptides: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase