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Displaying results 781 - 790 of 10000 in total
  1. Drug

    Sabestomig

    go.drugbank.com/drugs/DB19326
    Investigational

    Sabestomig is under investigation in clinical trial NCT05216835 (Safety and Preliminary Efficacy Assessment of AZD7789 in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma).

    Synonyms: Immunoglobulin G1-kappa/lambda, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279) and HAVCR2 (hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domains family member, Immunoglobulin G1 [239-phenylalanine,240-glutamic acid,336-serine,354-cysteine,371-serine,373-alanine,412-valine], bispecific, anti-(human programmed cell death protein 1) (human-Mus musculus clone LO115
  2. Drug

    Valsartan

    go.drugbank.com/drugs/DB00177
    ApprovedInvestigational

    In particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate fluid retention, vasoconstriction, and ultimately a further decline in left ventricular function. … ARBs such as valsartan have been shown in a number of large-scale clinical outcomes trials to improve cardiovascular outcomes including reducing risk of myocardial infarction, stroke, the progression of

    Synonyms: N-(P-(O-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine, (S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valineMixtures: CARDIK - IN® 160/2.5, CARDIK - IN® 160/2.5
  3. Pathway

    The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria

    smpdb.ca/view/SMP0002358
    Disease

    L-2-hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies. … This results in modulations of HIF-mediated hypoxia responses and alterations in gene expression through global epigenetic remodelling that may contribute to malignant transformation.

    Drugs: Pyruvic acid · Biotin · L-Glutamine · Succinic acid · Glutamic acid · NADH +6 more
  4. Drug

    Cefalotin

    go.drugbank.com/drugs/DB00456
    ApprovedVet approvedWithdrawn

    Cefalotin is a cephalosporin antibiotic.

    Synonyms: 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid, 7-(Thiophene-2-acetamido)cephalosporinCategories: Heterocyclic Compounds, 2-Ring
  5. Drug

    Cefazolin

    go.drugbank.com/drugs/DB01327
    ApprovedInvestigational

    A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

    Synonyms: (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidMixtures: CEFAMEZIN 250 MG IM ENJEKTABL TOZ İÇEREN FLAKON, 1 ADET, CEFAMEZIN 500 MG IM ENJEKTABL TOZ İÇEREN FLAKON, 1 ADET
  6. Drug

    Magnesium sulfate

    go.drugbank.com/drugs/DB00653
    ApprovedInvestigationalVet approved

    A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. … It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions.

    Mixtures: Magnesium Sulfate In 5% Dextrose Inj(20mg/ml), Vamin NSynonyms: magnesium(II) sulfate, Magnesium sulfate (1:1)
  7. Drug

    Bivalirudin

    go.drugbank.com/drugs/DB00006
    ApprovedInvestigational

    Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. … Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously.

    Products: Bivalirudin in 0.9% Sodium Chloride, ANGIOMAX® POLVO LIOFILIZADO PARA RECONSTRUIR A SOLUCIÓN INYECTABLE (50MG/ML)
  8. Drug

    Interferon alfa

    go.drugbank.com/drugs/DB05258
    ApprovedInvestigationalWithdrawn

    Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. Of these, IFN-α2 and IFN-α14 are glycosylated. … Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography.

    Categories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: IFN-α
  9. Pathway

    The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria

    smpdb.ca/view/SMP0002359
    Disease

    A mutation in IDH causes high concentrations of D-2-Hydroxyglutaric acid. D-2-hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies. … Hydroxyglutaric aciduria is a rare genetic disorder. Both isoforms are believed to have autosomal recessive inheritance.

    Drugs: Pyruvic acid · Biotin · L-Glutamine · Succinic acid · Glutamic acid · NADH +6 more
  10. Drug

    Insulin human

    go.drugbank.com/drugs/DB00030
    ApprovedInvestigational

    If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening … Human insulin is also available in an inhalable form, intended to be used as a bolus meal-time insulin.

    Mixtures: GENSULIN M 40 (40/60) 100 IU/ML, GENSULIN M 40 (40/60) 100 IU/MLCategories: Drugs Used in Diabetes, Cytochrome P-450 CYP1A2 Inducers