DB00456ApprovedVet approvedWithdrawnSmall molecule
Cefalotin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract.
- Mechanism
- Curator reviewed
The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized.
- Primary indication
- Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.Curator reviewed · 1 structured indication
- Formula / weight
- C16H16N2O6S2 · 396.438 g/mol (avg)
- First approval
- Canada, 2014
- Also known as
- Cefalothin · Cephalothin · Cephalotin
Resolves to
Clinical / RWD
Structure
InChIKey
XIURVHNZVLADCM-IUODEOHRSA-NSMILES[H][C@@]1(NC(=O)CC2=CC=CS2)C(=O)N2C(C(O)=O)=C(COC(C)=O)CS[C@]12[H]Targets
What you can answer from here — as of September 23, 2026
9Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
7TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Cefalotin, and which of those have an active Phase 3 trial?
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