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Bicalutamide
go.drugbank.com/drugs/DB01128ApprovedInvestigationalBicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen recep...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesPrednicarbate
go.drugbank.com/drugs/DB01130ApprovedPrednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio,...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProguanil
go.drugbank.com/drugs/DB01131ApprovedProguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofo...
Synonyms: 1-(p-Chlorophenyl)-5-isopropylbiguanideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesPioglitazone
go.drugbank.com/drugs/DB01132ApprovedInvestigationalPioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus. It is administered as a racemic mixture, though there is no pharmacologic difference betwee...
Mixtures: INCRESINA PCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesDesipramine
go.drugbank.com/drugs/DB01151ApprovedDesipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-dep...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesFloxuridine
go.drugbank.com/drugs/DB00322ApprovedInvestigationalAn antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous,...
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsEthambutol
go.drugbank.com/drugs/DB00330ApprovedInvestigationalEthambutol is a bacteriostatic agent indicated alongside medications such as isoniazid, rifampin, and pyrazinamide in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InhibitorsMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalMethadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorp...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProtriptyline
go.drugbank.com/drugs/DB00344ApprovedProtriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In...
Categories: P-glycoprotein inhibitorsTrimethadione
go.drugbank.com/drugs/DB00347ApprovedWithdrawnAn anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates