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Vindesine
go.drugbank.com/drugs/DB00309ApprovedInvestigationalWithdrawnVinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).
Synonyms: 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFluorometholone
go.drugbank.com/drugs/DB00324ApprovedInvestigationalA glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSulfadiazine
go.drugbank.com/drugs/DB00359ApprovedInvestigationalVet approvedOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesSecobarbital
go.drugbank.com/drugs/DB00418ApprovedVet approvedSecobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the...
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2C8 InducersCefpiramide
go.drugbank.com/drugs/DB00430ApprovedCefpiramide is a third-generation cephalosporin antibiotic.
Teniposide
go.drugbank.com/drugs/DB00444ApprovedInvestigationalTeniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and pr...
Synonyms: 4'-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesFluoxetine
go.drugbank.com/drugs/DB00472ApprovedInvestigationalVet approvedFluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly pre...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamineLercanidipine
go.drugbank.com/drugs/DB00528ApprovedInvestigationalWithdrawnLercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsAdinazolam
go.drugbank.com/drugs/DB00546ExperimentalAdinazolam (Deracyn®) is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was first developed to enhance the antidepressant effects of alprazolam. It has never been approved...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMethoxsalen
go.drugbank.com/drugs/DB00553ApprovedInvestigationalA naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 Inhibitors