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Chlorpromazine
go.drugbank.com/drugs/DB00477ApprovedInvestigationalVet approvedLike the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine, 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amineIsoprenaline
go.drugbank.com/drugs/DB01064ApprovedInvestigationalIsoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion … [L33204] Isoprenaline was granted FDA approval on 19 February 1948.[L33155]
Synonyms: N-Isopropylnoradrenaline, N-IsopropylnorepinephrineCategories: Non-selective Beta-adrenergic AgonistsMelphalan
go.drugbank.com/drugs/DB01042ApprovedInvestigational[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. … [L47890] It is also used to treat uveal melanoma with unresectable hepatic metastases.[L47895]
Synonyms: p-N,N-bis(2-chloroethyl)amino-L-phenylalanine, p-N-Bis(2-chloroethyl)amino-L-phenylalanineAducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigational[L34420] Biogen enrolled patients in phase 3 clinical trials in 2015 but increased the size of the trials from 1350 patients to 1650 patients to maintain statistical power in the face of a high standard … [A235668,A235720] Clinical trials showed a 23% relative difference between the experimental and placebo groups as determined by CDR; however, this is equivalent to an absolute difference of 0.4/18.
Pemetrexed
go.drugbank.com/drugs/DB00642ApprovedInvestigationalIts use in non-small cell lung cancer has also been investigated. Pemetrexed was first approved by the FDA in February 4, 2004.[A253907] … Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta.
Roflumilast
go.drugbank.com/drugs/DB01656ApprovedInvestigational[L46546] It was first approved by the EMA in July 2010, and by the FDA in January 2018.[L37564] Roflumilast topical cream is indicated to treat plaque psoriasis. … The cream formulation was first approved by the FDA in July 2022 [L42580] and by Health Canada in April 2023.
Categories: Agents to Treat Airway DiseaseCasimersen
go.drugbank.com/drugs/DB14984ApprovedInvestigationalDuchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and … Casimersen is currently marketed under the tradename AMONDYS 45™ by Sarepta Therapeutics, Inc.[L32118]
Padimate O
go.drugbank.com/drugs/DB11570ApprovedPadimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA [L2153]. … It penetrates human skin, and is shown to induce non-ligatable strand breaks on DNA _in vitro_ and mutagenic effects on yeast i_n vivo_ [A32458].
Mixtures: Dermatone SPF 23 Lips N Face ProtectorSynonyms: Padimate O, Padimate-OPeramivir
go.drugbank.com/drugs/DB06614ApprovedInvestigationalfor no more than two days. … Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B.
Calcium threonate
go.drugbank.com/drugs/DB11168ApprovedWithdrawnTherapeutic efficacy of calcium threonate in reducing was studied and investigated due to the hypothesis that it may play a role in the mineralization process through its positive action on vitamin C. … L-threonate is an active metabolite of vitamin C that mediates a stimulatory action on vitamin C uptake [A27266].
Mixtures: UltimateCare ONE NF