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Displaying results 801 - 810 of 10000 in total
  1. Pathway

    Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (Fatty Acid Elongation in Mitochondria)

    smpdb.ca/view/SMP0125748
    Disease

    MCADD is an autosomal recessive disorder associated with a mutation in the enzyme known as hydroxyacyl-CoA dehydrogenase (HADHA). … The estimated birth prevalence of LCHADD is 1 in 62 000 in Northern European individuals. The worldwide birth prevalence is estimated at 1 in 250 000.

    Drugs: NADH · Palmitic Acid
  2. Drug

    Erenumab

    go.drugbank.com/drugs/DB14039
    ApprovedInvestigational

    CGRP receptor, which is believed to play a critical role in migraine [L2823]. … Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only FDA approved treatment specifically developed to prevent migraine by blocking the

    Products: Pasurta 70mg/ml Solution for Injection in a Prefilled Syringe, AIMOVIG SOLUTION FOR INJECTION IN PRE-FILLED PEN 70MG/ML
  3. Drug

    Fenvalerate

    go.drugbank.com/drugs/DB18391
    Experimental

    Synonyms: methyl (R)-4-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-((4-((pyridin-3- ylmethyl)amino)butyl)amino)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate, -cyano-3-phenoxybenzyl (2rs)-2-(4-chlorophenyl)-3-methylbutyrateCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP2D6 Inhibitors
  4. Indication

    Hemophilia A

    go.drugbank.com/conditions/DBCOND0001634
    Drugs: Damoctocog alfa pegol · Desmopressin
    Synonyms: Haemophilia A, Hemophilia A
  5. Drug

    Cytarabine

    go.drugbank.com/drugs/DB00987
    ApprovedInvestigational

    A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. … Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle.

    Synonyms: 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone, 1-beta-D-ArabinofuranosylcytosineInternational brands: Ara-C, Cytosar-U
  6. Drug

    Bazlitoran

    go.drugbank.com/drugs/DB14990
    Investigational

    Bazlitoran is under investigation in clinical trial NCT02092909 (Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia).

    Synonyms: DNA, D(P-THIO)(C-T-A-T-C-T-RGM-RUM-M5C-C7G-T-T-C-T-C-T-RGM-RUM), ALL-P-AMBO-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOADENYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-O-METHYL-P-THIOGUANYLYL
  7. Drug

    Dupilumab

    go.drugbank.com/drugs/DB12159
    ApprovedInvestigational

    [L7186] Dupilumab is commonly marketed as Dupixent, which is available as a formulation for subcutaneous injection. It was first approved by the FDA in 2017. … [L41900] It is used as monotherapy or in combination with other drugs, such as corticosteroids.

    Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha AntagonistsProducts: DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 300 mg/2ml, DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 200 mg/1.14ml
  8. Drug

    Dacarbazine

    go.drugbank.com/drugs/DB00851
    ApprovedInvestigational

    An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). … Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.

    Synonyms: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamideCategories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index
  9. Drug

    Varicella zoster vaccine (live/attenuated)

    go.drugbank.com/drugs/DB10318
    ApprovedInvestigational

    Since October 2017, however, it has been replaced as first line therapy by Shingrix ([DB13924]), a more effective and longer lasting vaccine[L1038]. … , while Zostavax, a live attenuated vaccine, is contraindicated.

    Synonyms: Human herpesvirus 3 live (attenuated) antigenMixtures: Priorix - Tetra Pulver in einer Durchstechflasche und Lösungsmittel in einer Fertigspritze zur Herstellung einer Injektionslösung, PROQUAD® ( Measles, Mumps, Rubella AND Varicella (Oka/Merck) Virus Vaccine Live, MSD) LYOPHILIZED VACCINE;
  10. Drug

    Etevritamab

    go.drugbank.com/drugs/DB17211
    Investigational

    Synonyms: LINKER (GGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN A, anti-EGFRvIII x anti-CD3 bispecific T cell engager antibody construct