Hemophilia A (DBCOND0001634)

Identifiers

Synonyms
Hemophilia As / Haemophilia A / Classical hemophilia / Haemophilia A (Factor VIII) / Hemophilia A (Factor VIII) / Hemophilia A (disorder) / Congenital factor VIII disorder / Factor VIII deficiency / Factor VIII deficiency (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Antihemophilic factor (recombinant), PEGylated
For the management of hemophilia A (congenital factor VIII deficiency) [FDA label], . This medication is a human antihemophilic factor indicated in adolescent and adult patients (12 years and older)...
Antihemophilic factor human
A Factor VIII replacement therapy used to treat hemophilia A.
Antihemophilic factor, human recombinant
A form of recombinant coagulation Factor VIII used to treat hemophilia A, von Willebrand disease, and Factor XIII deficiency.
Beroctocog alfa
Beroctocog alfa is indicated for the prevention and control of bleeding in patients with hemophilia A or acquired Factor VIII (FVIII) deficiency. It is also indicated for surgical/invasive procedures in...
No drug targets
Coagulation factor VIIa Recombinant Human
A form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
Damoctocog alfa pegol
A recombinant Factor VIII used to treat hemophilia A to control bleeding, perioperative bleeding, and also for prophylaxis of bleeding.
Desmopressin
A synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
Efanesoctocog alfa
A recombinant DNA-derived, Factor VIII concentrate indicated for routine prophylaxis, on-demand treatment and control of bleeding episodes, and perioperative management of bleeding in patients with hemophilia A.
Efmoroctocog alfa
A recombinant Factor VIII used to treat and prevent bleeding in hemophilia A.
Factor IX Complex (Human)
A Factor IX complex used to prevent and treat bleeding episodes in hemophilia B or vitamin K antagonist therapy.
No drug targets
Lonoctocog alfa
A recombinant Factor VIII used to treat hemophilia A to control bleeding.
Susoctocog alfa
A recombinant Factor VIII used to treat and prevent bleeding in hemophilia A.
Turoctocog alfa
An antihemorrhagic agent used for the treatment and prophylaxis of bleeding in patients of all ages with haemophilia A (congenital factor VIII deficiency).
Von Willebrand factor human
A blood clotting factor used to manage bleeding episodes in von Willebrand disease and hemophilia A.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04645199
National Longitudinal Cohort of Hematological DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05681845
A Study to Compare the Blood Levels of Mim8 in Healthy Men When Administered With the DV3407-C1 Pen Injector or a Syringe and CartridgeNo drug interventionstreatment1completed
NCT06649630
A Study Looking at How Different Doses of Study Medicine (Inno8) Works in the Body of Healthy MenNo drug interventionstreatment1recruiting
NCT05053139
A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without InhibitorsNo drug interventionstreatment3recruiting
NCT05685238
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A (FRONTIER 4)No drug interventionstreatment3recruiting
NCT03055611
A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or BNot AvailableNot Availablecompleted
NCT06285071
Post-Marketing Surveillance (All Case Surveillance) on Treatment With Alhemo® in Patients With Haemophilia A or Haemophilia B With InhibitorsNot AvailableNot Availableenrolling_by_invitation
NCT06574984
Study for Turoctocog Alfa Treatment Regimen in Iraqi Haemophilia A PatientsNot AvailableNot Availablenot_yet_recruiting
NCT02035384
Safety and Efficacy of Turoctocog Alfa During Long-Term Treatment of Severe and Moderately Severe Haemophilia ANot AvailableNot Availablecompleted
NCT01562587
Pharmacokinetics of Single Bolus Dose of NovoSeven® in Paediatric and Adult Patients With Haemophilia A or B in a Non- Bleeding Statetreatment1completed
NCT04682145
Adverse Event Data Collection From the EUHASS Registry on Turoctocog Alfa PegolNot AvailableNot Availableenrolling_by_invitation
NCT03196297
A Trial Evaluating Efficacy and Safety of Prophylactic Administration of Concizumab in Patients With Severe Haemophilia A Without Inhibitorstreatment2completed
NCT01493778
Safety and Efficacy of Turoctocog Alfa in Prevention and Treatment of Bleeds in Previously Untreated Children With Haemophilia Atreatment3completed
NCT00837356
Comparison of the Action of Drugs in the Body and Safety of N8 and Advate® in Haemophilia A Subjectstreatment1completed
NCT01988532
Impact of Pain on Functional Impairment and Quality of Life in Adults With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT01272206
Investigating Safety and Pharmacokinetics of NNC 0128-0000-2011 Compared to NNC 0128-0000-2021 in Healthy Male SubjectsNo drug interventionstreatment1completed
NCT01555749
Investigation of the Pharmacokinetics of NNC172-2021, at Two Different Dose Levels, in Healthy Japanese SubjectsNo drug interventionstreatment1completed
NCT02207218
To Investigate Safety and Efficacy of NovoEight® (rFVIII) During Long-term Treatment of Haemophilia A in JapanNot AvailableNot Availablecompleted
NCT02300519
Thrombin Generation Numerical Models Validation in Haemophilic CaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05082116
Efficacy and Safety of Turoctocog Alfa Pegol (N8-GP) for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Chinese Patients With Haemophilia A (pathfinder10)treatment3completed
NCT04165135
An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT03276130
Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and BNo drug interventionsNot AvailableNot Availablecompleted
NCT00984126
Safety and Efficacy of Turoctocog Alfa (N8) in Prevention and On-demand Treatment of Bleeding Episodes in Subjects With Haemophilia A: An Extension to Trials NN7008-3543, NN7008-3545, NN7008-3600, NN7008-3893 and NN7008-4015treatment3completed
NCT02781766
TGA (Thrombin Generation Assay) and Prophylaxis in HaemophiliaNo drug interventionsotherNot Availableunknown_status
NCT03660774
A Study of the Impact of Hemophilia and Its Treatment on Brain Development, Thinking and Behaviour in Children With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT02250482
An Open Study to Investigate the Safety and Efficacy of Optivate® in Haemophilia A Patients Undergoing Surgery.treatment3completed
NCT00951873
A Single Dose Trial Investigating Safety and Local Tolerability of Ascending Doses of Long Acting Activated Recombinant Human Factor VII in Healthy Male Volunteerstreatment1completed
NCT04574076
A Study Following Males With Haemophilia A on Prophylaxis With Esperoct®Not AvailableNot Availableenrolling_by_invitation
NCT02207894
A Survey on the Success of Inhibitor Elimination Using Individualized Concentrate Selection and Controlled ITINo drug interventionsNot AvailableNot Availablerecruiting
NCT00922792
Safety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and Btreatment1completed
NCT01949792
A Trial Investigating the Pharmacokinetics and Pharmacodynamics of rFVIIa in Patients With Haemophilia A or B With or Without Inhibitorstreatment1completed
NCT01238367
A Single Dose Trial of Recombinant Factor VIII (N8) in Japanese Subjects With Haemophilia A: An Extension to Trial NN7008-3543treatment1completed
NCT01503567
Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing CountriesNo drug interventionsNot AvailableNot Availablecompleted
NCT01138501
Safety and Efficacy of Turoctocog Alfa in Previously Treated Male Children With Haemophilia Atreatment3completed
NCT02246868
An Open Study to Investigate the Safety and Efficacy of Optivate® in Severe Haemophilia A Patients.treatment3completed
NCT01228669
Safety of NNC 0172-0000-2021 in Healthy Male Subjects and Subjects With Haemophilia A or BNo drug interventionstreatment1completed
NCT03741881
A Study Following People With Haemophilia A and B, With or Without Inhibitors, When on Usual Treatment (Explorer™6)No drug interventionsNot AvailableNot Availablecompleted
NCT02137850
Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia Atreatment3completed
NCT02490787
Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of Concizumab Administered Subcutaneously to Haemophilia A Subjectstreatment1completed
NCT02941354
Evaluating the Pharmacokinetics of NovoEight® (Turoctocog Alfa) in Relation to BMI in Subjects With Haemophilia Atreatment1completed
NCT03528551
A Research Study Looking at How a Factor VIII Medicine Called Turoctocog Alfa Pegol (N8-GP) Works in People With Haemophilia Atreatment3completed
NCT01234545
Observational Study Describing the Usual Clinical Practice Use of NovoSeven® in the Home Treatment of Joint Bleeds in Patients With Haemophilia A or B and InhibitorsNot AvailableNot Availablecompleted
NCT02920398
A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia Atreatment1completed
NCT00245297
Study of the Efficacy of Human Recombinant Factor VIII (Kogenate FS) Reconstituted in Pegylated Liposomes.prevention2completed
NCT01489111
Evaluating the Haemostatic Effect of NNC 0129-0000-1003 During Surgical Procedures in Subjects With Haemophilia A.treatment3completed
NCT00486278
Haemophilia Patients With Inhibitors Being Treated for Acute Joint Bleedstreatment2completed
NCT03695978
Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02994407
Safety, Tolerability, and Pharmacokinetics Study of Turoctocog Alfa Pegol Injected Under the Skin in Patients With Haemophilia Atreatment1completed
NCT02938585
Efficacy and Safety of Turoctocog Alfa for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Chinese Patients With Haemophilia Atreatment3completed
NCT01731600
A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously Treated Paediatric Patients With Severe Haemophilia Atreatment3completed
NCT01811875
Post-Marketing Safety Study Following Long-Term Prophylactic OptivateTreatment in Subjects With Severe Haemophilia Atreatment4terminated
NCT03449342
Research Study to Look at Side Effects During Regular Injection With Factor VIII Medicine Named Turoctocog Alfa for a 8 Weeks Periodtreatment4completed
NCT01631942
A Multi-centre, Open Labelled, Multiple Dosing Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC 0172-2021 Administered Subcutaneously to Healthy Male Subjects and Haemophilia SubjectsNo drug interventionstreatment1terminated
NCT02049099
A Non-interventional Retrospective Study of the Current Treatment Practice in European Haemophilia CareNo drug interventionsNot AvailableNot Availablecompleted
NCT01220141
Observational Study on Safety of Room Temperature Stable NovoSeven® in Patients With Haemophilia A or BNot AvailableNot Availablecompleted
NCT03588741
Evaluation of Safety Following Immune Tolerance Induction Treatment With Turoctocog Alfa in Patients With Haemophilia A Following Inhibitor Development in NN7170-4213 Trialtreatment3terminated
NCT04675541
Register of Patients With haEmophilia A tReated With Afstyla®Not AvailableNot Availableactive_not_recruiting
NCT01205724
Safety and Pharmacokinetics of NNC 0129-0000-1003 in Subjects With Haemophilia Atreatment1completed
NCT06352216
Prevalence of Synovitis in Patients With Haemophilia ANo drug interventionsNot AvailableNot Availablerecruiting
NCT00853086
Post-marketing Safety Surveillance of NovoSeven® in Patients With Haemophilia and Inhibitors by Means of the UK Haemophilia DatabaseNot AvailableNot Availablecompleted
NCT00840086
Safety and Efficacy of Turoctocog Alfa in Haemophilia A Subjectstreatment3completed
NCT01692925
Investigation of the Pharmacokinetics of Turoctocog Alfa in Subjects With Haemophilia Atreatment1completed
NCT01436825
Validation Study of a cOmputer Pharmacokinetic Tool to assIst in the Follow up Care of haeMophilia A PatientsNot AvailableNot Availablecompleted
NCT03179748
Study Investigating Novoeight®/NovoEight® (Turoctocog Alfa) in Mexican Haemophilia A PatientsNot AvailableNot Availablecompleted
NCT01311648
BAY81-8973 Pediatric Safety and Efficacy Trialtreatment3completed
NCT04334057
Post-Marketing Surveillance (Use-results Surveillance) With Esperoct®Not AvailableNot Availableenrolling_by_invitation
NCT01562457
Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding Statetreatment1completed
NCT01365520
A Single Dose Trial of NNC 0155-0000-0004 in Patients With Haemophilia Atreatment1completed
NCT01322620
Survey Evaluating the Psychosocial Effects of Living With HaemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT02246894
A Study to Investigate the Safety and Efficacy of Optivate® in Children Under 6 Years of Age With Haemophilia A.Not Available3completed
NCT02241694
To Quantify the Range of Main Psychosocial Factors Affecting Patients and Caregivers in Their Daily LivesNo drug interventionsNot AvailableNot Availablecompleted
NCT01288391
Investigating Safety and Pharmacokinetics of 2 Different Single Doses of NNC128-0000-2011 in Haemophilia A or B PatientsNo drug interventionstreatment1completed
NCT01480180
Evaluation of Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Subjects With Haemophilia Atreatment3completed
NCT04584892
Turoctocog Alfa in Haemophilic Italian Patients: Protection and Engagement in Recreational ActivitiesNot AvailableNot Availablecompleted
NCT00638001
Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle ArthropathyNo drug interventionstreatment4completed
NCT05621746
An Observational Research Study of the Health of Joints in People With Haemophilia Taking the Medicine EsperoctNot AvailableNot Availablerecruiting
NCT02084810
Investigating the Bioequivalence of Eptacog Alfa A 6 mg and NovoSeven® in Healthy Male Subjectstreatment1withdrawn
NCT01959555
Project to Update the Study of Congenital Haemophilia in SpainNo drug interventionsNot AvailableNot Availablecompleted
NCT05878938
A Research Study Looking at How Safe it is to Switch From Emicizumab to Mim8 in People With Haemophilia A (FRONTIER 5)No drug interventionstreatment3active_not_recruiting
NCT05932914
Liver Biopsy Following Gene Therapy For HemophiliaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05987449
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia ANo drug interventionstreatment1 / 2recruiting
NCT06568302
The Long-term Safety and Efficacy of SerpinPC in Subjects with Hemophilia Who Completed a Sponsored SerpinPC Clinical Trialtreatment3recruiting
NCT06649175
Effect of Kinetic Chain Exercises on Muscle Strength, Joint Position Sense and Quality of Life in Children with Haemophilia.No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06530030
Goal Attainment and Physical Activity in People With Hemophilia ANot AvailableNot Availablenot_yet_recruiting
NCT02941783
Drug Use Investigation of Kovaltry in Hemophilia A PatientsNot AvailableNot Availableactive_not_recruiting
NCT03587116
A Study to Evaluate Prospective Efficacy and Safety Data of Current FIX Prophylaxis Replacement Therapy in Adult Hemophilia B Subjects (FIX:C≤2%) or Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Subjects (FVIII:C≤1%)No drug interventionsother3active_not_recruiting
NCT03938792
Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia Btreatment3active_not_recruiting
NCT05145127
Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitorstreatment3recruiting
NCT05568719
Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B RespectivelyNo drug interventionsother3recruiting
NCT05611801
A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia Btreatment3recruiting
NCT06634836
Patient Interview Study to Explore the Impact of Gene Therapy in Hemophilia A & BNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02976753
Prospective, Non-interventional Study to Evaluate the Effectiveness of Elocta Compared to Conventional Factor ProductsNot AvailableNot Availablecompleted
NCT04293523
A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint HealthNot AvailableNot Availableactive_not_recruiting
NCT05036278
Prophylaxis Regimen for Hemophilia A Patientstreatment4active_not_recruiting
NCT05147662
A Study to Learn How Safe the Study Treatment BAY94-9027 is and How it Affects the Body in Previously Treated Children Aged 7 to Less Than 12 Years With Severe Hemophilia A, a Genetic Bleeding Disorder That is Caused by the Lack of a Protein Called Clotting Factor 8 (FVIII) in the Bloodtreatment3active_not_recruiting
NCT06222697
A Study to Learn More About the Safety of Damoctocog-alfa-pegol When Used in Routine Medical Care in Korean Participants With Hemophilia ANot AvailableNot Availablerecruiting
NCT04563520
SAFE Study: Safety of aPCC Following Emicizumab Prophylaxistreatment3recruiting
NCT04731701
Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST)No drug interventionsNot AvailableNot Availablecompleted
NCT05248594
Real World Use of Emicizumab in Infants and Children Ages 0-3 Years With Hemophilia ANot AvailableNot Availablerecruiting
NCT05605678
Hemophilia Non-Interventional Study Prior to SerpinPC Intervention (PRESent-5)No drug interventionsNot AvailableNot Availablerecruiting
NCT05707351
A Study of Adynovate in Previously Treated Chinese Teenagers and Adults With Severe Hemophilia Atreatment3completed
NCT05789524
The Efficacy and Safety of SerpinPC in Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia Btreatment2recruiting
NCT06025552
Study of TU7710 in Warfarin Anti-coagulated Healthy Male SubjectsNo drug interventionstreatment1completed
NCT06349473
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B)No drug interventionstreatment1recruiting
NCT04677803
BT200 in Hereditary Bleeding Disorderstreatment2completed
NCT04805021
Acquired Hemophilia A and Autoimmunity. Study of Lymphocyte Populations and Myeloid-Derived Suppressor CellsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02622321
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitorstreatment3completed
NCT02492984
PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Hemophilia Atreatment4completed
NCT01064284
Survey of Inhibitors in Plasma-Product Exposed Toddlersbasic_science4completed
NCT03327779
World Bleeding Disorders RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT01159587
Prophylaxis Versus On-demand Therapy Through Economic ReportNot AvailableNot Availablecompleted
NCT02479087
Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patientstreatment4unknown_status
NCT02911233
Evaluation of Clot Stability Induced by Solulin: Evaluation of New Solulin Mutants Lacking Protein C Activation CapacityNo drug interventionsNot AvailableNot Availablecompleted
NCT03003533
A Gene Transfer Study for Hemophilia ANo drug interventionstreatment1 / 2completed
NCT00281333
The Influence of "Karate" on Bleeding in Hemophilic Patients.No drug interventionspreventionNot Availableterminated
NCT04560933
A Study to Evaluate Seroprevalence and Seroconversion of Antibodies to Adeno-Associated Virus (AAV) in Patients With Hemophilia ANo drug interventionsNot AvailableNot Availablecompleted
NCT04370054
Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adultstreatment3active_not_recruiting
NCT00168051
Study Comparing Blood Levels of ReFacto and Advante in Hemophilia Atreatment4withdrawn
NCT03747653
A Study to Evaluate the Pharmacokinetics of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for InjectionNot AvailableNot Availableunknown_status
NCT02807753
The Hemophilia Ultrasound ProjectNo drug interventionsNot AvailableNot Availableterminated
NCT00157053
Study of Pharmacokinetics, Efficacy and Safety of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Hemophilia A Patients - A Continuation of Clinical Study 069901treatment2 / 3completed
NCT05980377
Patterns of Hemophilia Care in Assiut Children PatientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01460147
Osteoporosis and MRI Study in HemophiliaNo drug interventionsdiagnosticNot Availableterminated
NCT02727647
Comparison of Different Prophylaxis Regimens for Moderate to Severe Hemophilia A Pediatric Patientstreatment4completed
NCT02921945
Efficacy and Safety Study of SCT800 for On-demand Treatment With in Patients With Hemophilia Atreatment3unknown_status
NCT03417245
A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients Without Inhibitorstreatment3completed
NCT02895945
BAX 802 in CHA With Inhibitorstreatment3terminated
NCT00936845
Females With Severe or Moderate Hemophilia A or B: A Multi-Center StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04941898
A Study of TAK-660 in Surgical Procedures for People With Hemophilia A.Not AvailableNot Availablecompleted
NCT00157105
Safety and Efficacy Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Hemophilia A Patients Undergoing Surgerytreatment2 / 3completed
NCT06212505
EVALUATION OF THE OVERALL HAEMOSTATIC CAPACITY OF MIM8 WITH GLOBAL HAEMOSTASIS ASSAYS AND FIBRIN CLOT ULTRASTRUCTURENo drug interventionsNot AvailableNot Availablerecruiting
NCT02035605
A Phase 1 Study of an Investigational Drug, ALN-AT3SC, in Healthy Volunteers and Hemophilia A or B Patientstreatment1completed
NCT00207597
Joint Outcome StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03185897
Global Epidemiologic Study of Preexisting Immunity to AAV in Adults With Severe HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT00922597
Non-interventional Observation of Practical Implementation, Efficacy and Safety of Continuous Infusion With KOGENATE Bayer in SurgeryNot AvailableNot Availablecompleted
NCT05449197
Evaluation of the Training Program for Community Pharmacists for Dispensing Emicizumab (HEMLIBRA®) in FranceNo drug interventionsNot AvailableNot Availablecompleted
NCT02225483
Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet FunctionNo drug interventionsNot AvailableNot Availablecompleted
NCT05523128
The Efficacy and Safety of ZS802 in Chinese Hemophilia A Patients.No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01790828
Post Marketing Surveillance To Observe Safety And Efficacy Of Xyntha® In Subjects With Hemophilia ANot AvailableNot Availablecompleted
NCT01580293
A Trial Investigating Safety and Efficacy of Treatment With BAY94-9027 in Severe Hemophilia Atreatment2 / 3completed
NCT00947193
Study of Ataluren (PTC124) in Hemophilia A and Btreatment2terminated
NCT00007371
Hepatitis C in Clinically Discordant Hemophilic SiblingsNo drug interventionsNot AvailableNot Availablecompleted
NCT00279578
Clot Formation and Clot Stability in Patients With Severe Haemophilia AtreatmentNot Availablecompleted
NCT00178607
Covalent Tolerance Induction to Factor VIII-Prediction of Inhibitors in HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT00038909
Study Evaluating ReFacto in Hemophilia ANo drug interventionstreatmentNot Availablecompleted
NCT04061109
Safety, Efficacy Evaluation of Recombinant Coagulation Factor VIII Injection in Subjects With Hemophilia A.No drug interventionsprevention3unknown_status
NCT00357656
Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgerytreatment4completed
NCT04590456
Pulsed Electromagentic Field in HaemophiliaNo drug interventionstreatmentNot Availableunknown_status
NCT02392156
Fc factOrs and Real-World hemophiliA Patient-ReporteD OutcomesNot AvailableNot Availableterminated
NCT02750085
Evaluation of a Simple Pharmacokinetic Tool (myPKFiT™) to Guide Personalized Factor VIII Dosing in Patients With HemophiliaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02847637
A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitorstreatment3completed
NCT00916032
Pharmacokinetic Study of ADVATE 3000 IU in Previously Treated Patients With Severe Hemophilia Atreatment4completed
NCT00864552
International PMS Study - KOGENATE BayerNot AvailableNot Availablecompleted
NCT04953000
A Study of Standard and Individualized Prophylactic Treatment With Advate in Men and Boys With Severe Hemophilia ANo drug interventionsNot AvailableNot Availablecompleted
NCT00212459
The Effect of Patient Counseling on Adolescent Hemophilia Patient Compliance With Bleeding LogsNo drug interventionsNot AvailableNot Availablecompleted
NCT00243659
Study Evaluating B-Domain Deleted Recombinant Factor VIII (BDDrFVIII, ReFacto AF) in Patients With Hemophilia A Undergoing Elective Major Surgerytreatment3completed
NCT04644575
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia Atreatment3active_not_recruiting
NCT01736475
Study Investigating a PEGylated Recombinant Factor VIII (BAX 855) for Hemophilia A (PROLONG-ATE Study)prevention2 / 3completed
NCT03603275
Assessing Physician and Hemophilia A Patient Reasons and Expectations for Switching Treatment to Kovaltry & Jivi: A Nested Study Within an Existing RegistryNot AvailableNot Availableterminated
NCT02319070
2-cohort Study of Adult Patients With Severe Hemophilia A in GreeceNo drug interventionsNot AvailableNot Availablecompleted
NCT00306670
Trial of Rituximab Versus Oral Cyclophosphamide to Eradicate or Suppress Autoimmune Anti-Factor VIII Antibodies in Acquired Hemophilia Atreatment2 / 3terminated
NCT05439642
Validation and Reliability of the CHO-KLAT in TurkishNo drug interventionsdiagnosticNot Availableunknown_status
NCT03103542
Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapiestreatment4completed
NCT02476942
A Prospective Study to Collect High-Quality Documentation of Bleeds, Health-Related Quality of Life (HRQoL), and Safety Outcomes in Patients With Hemophilia A Treated With Standard-of-Care TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT04845399
Phase III Expansion Trial for Determining the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia Atreatment3completed
NCT03191799
A Study to Evaluate the Safety and Tolerability of Prophylactic Emicizumab in Hemophilia A Patients With Inhibitorstreatment3completed
NCT00666406
Pharmacokinetic Comparison of Advate rAHF-PFM With Recombinate rAHF in Patients With Severe Hemophilia Atreatment4completed
NCT00331006
Rituximab to Treat Severe Hemophilia Atreatment2completed
NCT05879549
Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises Patient With HemophiliaNo drug interventionstreatmentNot Availablerecruiting
NCT04131036
Effects of Emicizumab vs. Factor VIII Prophylaxis on Joint and Bone Health in Severe Hemophilia ANo drug interventionsNot AvailableNot Availablerecruiting
NCT05187936
Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic ArthropathyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05981313
Viscoelastic Properties of Lower Extremity Muscles in Patients With HemophiliaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02740413
Treatment Patterns And Outcomes In Patients Treated With Benefix Or Refacto/Refacto AF - A Swedish Cohort StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00005518
Epidemiology and Immunology of Hemophilia A InhibitorsNo drug interventionsNot AvailableNot Availablecompleted
NCT03815318
Evaluation of SCT800 in Prophylaxis Therapy on Previous Treated Patients With Severe Hemophilia Aprevention3completed
NCT01510418
Socialization of Adult Men With Congenital Hemophilia A or BNo drug interventionsNot AvailableNot Availablecompleted
NCT01599819
BAX 855 Dose-Escalation Safety Studytreatment1completed
NCT00969319
Effekt-2 - Efficacy and Safety of Long-term Treatment With KOGENATE® FS in Latin AmericaNot AvailableNot Availablecompleted
NCT01959919
Evaluation Of Acceptability And Satisfaction Of Hemophilia Patients Treated With FusENGONo drug interventionsNot AvailableNot Availablecompleted
NCT04023019
Treatment of Hemophilia A Patients With FVIII InhibitorsNot AvailableNot Availablerecruiting
NCT04728841
Gene Therapy for Chinese Hemophilia ANo drug interventionstreatmentNot Availablerecruiting
NCT04728217
Health Related Quality of Life of Youth and Young Adults With Haemophilia Aprevention4completed
NCT02930317
Evaluate Efficacy and Safety of Recombinant Factor VIII (rFVIII)Treatment of Severe or Moderately Severe Hemophilia Atreatment3unknown_status
NCT02199717
An Institutional Pilot Study to Investigate Physical Activity Patterns in Boys With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT06158334
Study of Surgical Practices in Patients With Haemophilia A or B Treated With an Extended Half-life Recombinant Factor VIII-Fc or IX-Fc (ELOCTA®, ALPROLIX®)Not AvailableNot Availablerecruiting
NCT00214734
ADVATE Post Authorization Safety SurveillanceNot AvailableNot Availablecompleted
NCT02634424
PK Driven Prophylaxis for Hemophilia ANo drug interventionssupportive_careNot Availableterminated
NCT03205163
A Safety, Tolerability, and Pharmacokinetics Study of a Single Intravenous Injection of Recombinant Coagulation Factor VIII Fc - Von Willebrand Factor - XTEN Fusion Protein (rFVIIIFc-VWF-XTEN) (BIVV001) in Previously Treated Adults With Severe Hemophilia A (EXTEN-A)other1 / 2completed
NCT00243386
Prophylaxis Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia Atreatment4completed
NCT06297486
Study of a Gene Therapy Treatment for Hemophilia ANo drug interventionstreatment3recruiting
NCT04396639
Moroctocog Alfa (AF-CC) for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Hemophilia A Patientstreatment4completed
NCT00543439
Study Evaluating Prophylaxis Treatment & Characterizing Efficacy, Safety, & PK Of B-Domain Deleted Recombinant FVIIItreatment3completed
NCT02726139
Improved Factor VIII Inhibitor EvaluationNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03204539
INdividualized ITI Based on Fviii(ATE) Protection by VWFtreatment4terminated
NCT01454739
Long-Term Safety and Efficacy of rFVIIIFc in the Prevention and Treatment of Bleeding Episodes in Previously Treated Participants With Hemophilia Atreatment3completed
NCT04690322
POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapiestreatment4recruiting
NCT02971930
Exit Interviews to Assess Impact of Infusion Frequency in Hemophilia ANot AvailableNot Availablecompleted
NCT00868530
Study Evaluating On-Demand Treatment Of Xyntha In Chinese Subjectstreatment3completed
NCT03001830
Gene Therapy for Haemophilia A.No drug interventionstreatment1 / 2recruiting
NCT04676048
ASC618 Gene Therapy in Hemophilia A Patientstreatment1 / 2recruiting
NCT00717626
Once-A-Day Prophylaxis for Youth and Young Adults With Severe Hemophilia Atreatment2completed
NCT00874926
EFFEKT - Efficacy and Safety of Long-term Treatment With KOGENATE Bayer/FSNot AvailableNot Availablecompleted
NCT00765726
Study Evaluating The Safety Of Xyntha In Usual Care Settingstreatment4terminated
NCT02263066
Retrospective Study in Chinese Pediatric Hemophilia A Patients With rFⅧ Contained Regular ProphylaxisNo drug interventionsNot AvailableNot Availablecompleted
NCT02962765
Non-interventional Post-authorisation Study to Document the Immunogenicity, Safety, and Efficacy of NUWIQNo drug interventionsNot AvailableNot Availablecompleted
NCT06273865
Version Testing of EnzySystem Version A for Hemophilia ANo drug interventionsNot AvailableNot Availablesuspended
NCT04876365
A Study in Children, Teenagers and Adults With Severe Hemophilia A Who Switched From Other Factor VIII Treatments to AdynovateNo drug interventionsNot AvailableNot Availablecompleted
NCT03379974
Exercise Versus DDAVP in Patients With Mild Hemophilia Atreatment4completed
NCT03947320
Safety,Efficacy and Pharmacokinetics Evaluation of SCT800 in Previously Treated Paediatric Patients With Severe Haemophilia A.prevention3unknown_status
NCT03432520
Long-Term Safety and Efficacy of Spark-Sponsored Gene Therapies in Males With Hemophilia ANo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01184820
Trial to Evaluate the Pharmacokinetics and Safety Profile of BAY94-9027 Following Single and Multiple Dose Administrationbasic_science1completed
NCT00189982
Efficacy and Safety Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Pediatric Patients in Canada With Hemophilia A - A Continuation of Baxter Study 060101No drug interventionstreatment2 / 3completed
NCT03507582
Virtual Reality for HemophiliaNo drug interventionsotherNot Availablecompleted
NCT04985682
A Study of ADVATE in People With Hemophilia A in Indiatreatment4completed
NCT01541527
Non Neutralizing Antibodies: Prevalence and CharacterizationNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03834727
Characterizing the Impact and Treatment of Reproductive Tract Bleeding on Women and Post-menarchal Girls With Bleeding DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT01486927
An Open-label Safety, Efficacy and Pharmacokinetic Study of a Recombinant FVIII Compared to Recombinant Human Antihemophilic FVIII in Patients With Severe Hemophilia Atreatment2 / 3completed
NCT02078427
ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)Not AvailableNot Availablecompleted
NCT01652027
Hemophilia Inhibitor Previously Untreated Patient StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00092976
Study Evaluating ReFacto® in Hemophilia A Undergoing Major Surgerytreatment4completed
NCT02585960
BAX 855 PK-guided Dosingprevention3completed
NCT02582060
Individualizing Hemophilia Prophylaxis Using ThromboelastographyNo drug interventionsotherNot Availablecompleted
NCT05643560
An Observational Study Called JOIHA to Learn More About How Well the Treatment With Jivi Works to Prevent Problems With Joints in Adults With Hemophilia ANot AvailableNot Availablerecruiting
NCT02716194
BAX 826 Dose-Escalation Safety Studytreatment1completed
NCT01568580
Efficacy and Safety of Recombinant Factor VIII (GreenGene) in Patients With Hemophilia ANo drug interventionstreatment3completed
NCT00623480
Trial to Evaluate the Effect of Secondary Prophylaxis With rFVIII Therapy in Severe Hemophilia A Adult and/or Adolescent Subjects Compared to That of Episodic Treatmenttreatment3completed
NCT03380780
A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Emicizumab in Healthy Chinese Volunteerstreatment1completed
NCT03818529
ATHN 8: Previously Untreated Patients (PUPs) Matter StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00994929
Efficacy and Safety of IL-11 in DDAVP Unresponsivetreatment2completed
NCT02461992
Study of PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Male Chinese Subjects With Hemophilia Abasic_science1completed
NCT04015492
Study to Compare How the Body Distributes and Excretes the Drugs Jivi (BAY 94-9027) and Adynovi in Patients With Severe Hemophilia A (Bleeding Disorder Resulting From a Lack of Blood Clotting Factor VIII)treatment1completed
NCT06579144
Pharmacokinetic Comparison of Efanesoctocog Alfa vs Other EHL-rFVIII Products in Participants With Severe Haemophilia Aother1not_yet_recruiting
NCT00157040
Study of Pharmacokinetics, Efficacy, and Safety of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Pediatric Patients With Hemophilia Atreatment2 / 3completed
NCT05450640
Satisfaction Regarding the Dispensing of Emicizumab (HEMLIBRA®) for Patients With Haemophilia A in FranceNo drug interventionsNot AvailableNot Availablecompleted
NCT01029340
Trial to Evaluate the Efficacy and Safety of a New Full Length Recombinant Human FVIII for Hemophilia Atreatment3completed
NCT05606640
Gaining Insight Into the Complexity of Pain in Patients With HaemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT03876301
Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A ParticipantsNo drug interventionsNot AvailableNot Availablecompleted
NCT03533504
Web Accessible Population Pharmacokinetics Service - Hemophilia: Sources of VariabilityNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01034904
Health Related Quality of Life of Youth and Young Adults With Hemophilia ANo drug interventionsNot AvailableNot Availablecompleted
NCT06357572
Real-life Clinical FEIBA Samples Measured Using the Version A of the HemA EnzySystemNo drug interventionsNot AvailableNot Availablecompleted
NCT02061072
Web-based Application for the Population Pharmacokinetic Service - Phase 1No drug interventionsNot AvailableNot Availablecompleted
NCT02528968
National Study of a Pharmacokinetic-Focused Educational Package for Patients With Severe Haemophilia ANo drug interventionsotherNot Availablecompleted
NCT02571569
A Single Escalating Dose and Multiple Dose Study of BAY 1093884 in Subjects With Severe Hemophilia Types A or B, With or Without Inhibitorsbasic_science1completed
NCT04472169
UPLC-MS/MS Monitoring of Emicizumab TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT02622646
Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01619046
Safety, Efficacy and Pharmacokinetics of GreenGene™ F to Previously Treated Patients With Severe Hemophilia Atreatment3unknown_status
NCT00936312
Females With Severe or Moderate Hemophilia A or B: an International Multi-center StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06565481
Measurement Properties in People With HemophiliaNo drug interventionsotherNot Availablenot_yet_recruiting
NCT00797381
Efficacy and Safety of MK-0518 in Treatment-Experienced HIV-1 Infected Adult Patients With HemophiliaNo drug interventionsNot AvailableNot Availableunknown_status
NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene DisordersNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00932555
EffeKt Taiwan- Efficacy and Safety of Long-term Treatment With KOGENATE® FS in TaiwanNot AvailableNot Availablecompleted
NCT01921855
Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without Inhibitorstreatment1completed
NCT04845555
Association Between Individual Clotting Factor Level Monitoring and the Risk of Bleeding Whilst Physical Active ConditionsNo drug interventionsNot AvailableNot Availableunknown_status
NCT00759655
Study Evaluating The Efficacy And Safety Of Xyntha In Children Less Than 6 Years Of Agetreatment3terminated
NCT06297655
A Clinical Study of Recombinant Human Coagulation Factor VIII for Injection in Patients With Severe Hemophilia Atreatment3not_yet_recruiting
NCT02172950
An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia ANo drug interventionstreatment3completed
NCT02234323
An Open Label Study to Determine the Safety and Efficacy of Replacement Factor VIII Protein (Known as rFVIIIFc) in Previously Untreated Males With Severe Hemophilia Atreatment3completed
NCT02506023
Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriersdiagnostic1completed
NCT02634723
Retrospective Chart Review to Evaluate Safety and Tolerability of ADVATE Among Previously Untreated Patients in China With Moderate to Severe Hemophilia ANot AvailableNot Availablecompleted
NCT03655223
Early Check: Expanded Screening in NewbornsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT02483208
Single Dose Study in Subjects With Severe Hemophilia A Comparing Pharmacokinetic Parameters for BAY81-8973 and Advatebasic_science1completed
NCT06238908
Safety and Efficacy Study of NGGT003 in Hemophilia A PatientsNo drug interventionstreatment0not_yet_recruiting
NCT06111638
Evaluation of the Safety and Efficacy of Hemophilia A Gene Therapy DrugsNo drug interventionstreatment1 / 2recruiting
NCT02912143
German Pediatric Hemophilia Research DatabaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01579903
Relative Bioavailability Of Two Formulations Of Moroctocog Alfa (AF-CC)Not Available1completed
NCT03344003
Immune Tolerance Induction in Haemophilia A Patients Using Wilate or NuwiqNot AvailableNot Availableterminated
NCT05856903
Impact of Emicizumab on Activated Clotting Time Using the i-STAT Alinity AnalyzerNo drug interventionsNot AvailableNot Availablerecruiting
NCT00884390
Study Evaluating Safety Of Patients Switching To ReFacto AF In Usual Care Settingstreatment4terminated
NCT05251090
A Study to Evaluate the Safety and Pharmacokinetic of Recombinant Human Coagulation Factor VIII ,Fc Fusion Protein for Injectiontreatment1completed
NCT00586521
BAY14-2222 Prophylaxis and Joint Function Improvement (Adults)treatment4completed
NCT00851721
Efficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia A or B and a High Titer Inhibitortreatment3completed
NCT00839202
Activity and Content of Factor VIII (FVIII) in Human Plasma: The Assessment of a Novel ImmunoassayNo drug interventionsbasic_scienceNot Availablecompleted
NCT03417102
A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients With Inhibitorstreatment3completed
NCT02170402
China ADVATE PTP Studyprevention4completed
NCT02027779
Safety and Efficacy Extension Study of GreenGene™ F in Previously Treated Patients Diagnosed With Severe Hemophilia ANo drug interventionstreatment3unknown_status
NCT04456387
An Open Label Study to Determine the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A.treatment3completed
NCT02061033
Global Hemostatic Methods in Hemophilia and Von Willebrand's DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT03615053
Personalized Medicine for Canadians With HemophiliaNo drug interventionsotherNot Availablerecruiting
NCT03286153
Comparison of Ideal vs. Actual Weight Base Factor DosingNo drug interventionshealth_services_researchNot Availableunknown_status
NCT02718677
Patient-reported Outcomes in Subjects Treated With ReFacto AF Routine ProphylaxisNot AvailableNot Availablewithdrawn
NCT00245245
Study of Recombinant Porcine Factor VIII (FVIII) in Hemophilia and Inhibitors to FVIIItreatment2completed
NCT04073498
The Safety and Tolerability of SerpinPC in Healthy Men and in Men With Severe Blood Disorders (Haemophilia A and B)treatment1 / 2active_not_recruiting
NCT03364998
BAY94-9027 PK Study Comparing to Another Long Acting Productbasic_science1completed
NCT00824798
Gait Evaluation in Haemophiliac PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04323098
Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia Atreatment3active_not_recruiting
NCT01757405
Recombinant Factor VIIa BI (rFVIIa BI) Treatment of Acute Bleeding Episodes Per an On-demand Regimentreatment3completed
NCT01913405
Phase 3 Efficacy and Safety Study of BAX 855 in Severe Hemophilia A Patients Undergoing Surgical Procedurestreatment3completed
NCT00000705
Safety and Effectiveness of Azidothymidine (AZT) in HIV-Positive Patients With Hemophiliatreatment1completed
NCT01626105
Personalized Prediction of Tolerance and Immunogenicity in HemophiliaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00005305
Hepatitis Delta Infections in HemophiliacsNo drug interventionsNot AvailableNot Availablecompleted
NCT01445197
Study of Biostate for Treatment of Children With Hemophilia A Complicated by Antibody DevelopmentNo drug interventionstreatment3terminated
NCT02674997
GAS-Hem Feasibility StudyNot AvailableNot Availablecompleted
NCT04133883
Impact on French Physician's Haemophilia Treatment Management Decision Based on Systematic Joint ExaminationNo drug interventionshealth_services_researchNot Availablecompleted
NCT04541628
Safety & Efficacy of Encapsulated Allogeneic FVIII Cell Therapy in Haemophilia Atreatment1 / 2terminated
NCT01434511
Study of Modified Recombinant Factor VIII (OBI-1) in Subjects With Congenital Hemophilia ANo drug interventionstreatment3terminated
NCT00284193
Combination Therapy of Low Doses of rFVIIa and FEIBA for Severe Hemophilia A Patients With an Inhibitor to Factor VIIItreatment4completed
NCT01945593
BAX 855 Continuationprevention3completed
NCT02418793
A Study of a Long-Acting r-Factor 7a (Factor VIIa) in Adult Men With Hemophilia A or Btreatment1completed
NCT01439971
Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophiliabasic_science1completed
NCT04784988
Intensive Replacement Treatment in Haemophilia Patients With SynovitisNo drug interventionstreatment4completed
NCT01229007
Study of Biostate® in Children With Hemophilia ANo drug interventionstreatment3completed
NCT01318707
Biomarkers Serum Collection Methodology Pilot StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06224907
Phase 3 Study for Efficacy and Safety Outcomes Data in Japanese Patients With Severe Hemophilia Atreatment3active_not_recruiting
NCT00005309
Prospective Study of HIV Infection in HemophiliacsNo drug interventionsNot AvailableNot Availablecompleted
NCT02938156
UK - EHL Outcomes RegistryNo drug interventionsNot AvailableNot Availableunknown_status
NCT00151385
Study Evaluating Inhibitor Specificity in Hemophilia ANo drug interventionsdiagnostic4withdrawn
NCT01053715
Quality of Life Study of Helixate NexGenNo drug interventionsNot AvailableNot Availablecompleted
NCT00629837
Pharmacokinetics and Safety of a Single Intravenous Infusion of BAY 79-4980treatment1completed
NCT01477437
Internet-based Educational Program to Promote Self-Management for Teens With HemophiliaNo drug interventionssupportive_careNot Availablecompleted
NCT03405337
Evaluation of Patient and Physician Reported Reasons for Switching Factor VIII Replacement TherapiesNo drug interventionsNot AvailableNot Availablecompleted
NCT03154437
An Expanded Access Program of Emicizumab in Participants With Hemophilia A With InhibitorsNot AvailableNot Availableapproved_for_marketing
NCT04072237
Study of Coagulation Faction VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With HemophiliaNo drug interventionsdiagnostic1completed
NCT03361137
Study of Emicizumab Prophylaxis in Participants With Hemophilia A With or Without Inhibitors Undergoing Minor Surgical Procedurestreatment4terminated
NCT00895037
Study Evaluating Pharmacovigilance Of Refacto AFNot AvailableNot Availablecompleted
NCT03217032
Lentiviral FVIII Gene TherapyNo drug interventionstreatment1unknown_status
NCT04030052
Emicizumab PUPs and Nuwiq ITI Studyprevention3withdrawn
NCT01376700
Early Prophylaxis Immunologic Challenge (EPIC) Studyprevention3terminated
NCT05022459
Prevention of Bleeding in Patients With Moderate and Severe Hemophilia A Playing Sports: A Comparison Between Factor VIII and Emicizumab ProphylaxisNot AvailableNot Availablerecruiting
NCT00914459
Study Evaluating Safety And Efficacy Of Moroctocog Alfa (AF-CC) In Previously Treated Hemophilia A Patientstreatment4completed
NCT04541875
Medication Adherence and Non-adherence in Adults With Rare DiseaseNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00950170
Study of Safety And Efficacy Of ReFacto AF In Previously Untreated Hemophilia A Patients In The Usual Care SettingNo drug interventionsother4completed
NCT00195442
Study Evaluating Refacto For PharmacovigilanceNot AvailableNot Availablecompleted
NCT03588299
Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a "Shuttle".treatment1 / 2active_not_recruiting
NCT01458106
Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Pediatric Subjects With Hemophilia Atreatment3completed
NCT01090206
Correlation Between Vitamin D Status and Bone Mineral Density in Patients With HemophiliaNo drug interventionsscreeningNot Availablecompleted
NCT02190149
Study of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBISNot AvailableNot Availablecompleted
NCT00289536
Dose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia Atreatment4completed
NCT04060836
Pharmacokinetics Evaluation of Recombinant Coagulation Factor VIII Injection in Subjects With Hemophilia A.prevention1unknown_status
NCT04303936
PHYSICAL ACTIVITY AND FVIII CLEARANCE: RELEVANCE FOR PERSONALIZED THERAPY IN SEVERE HAEMOPHILIA A (PHYSEMO)No drug interventionsotherNot Availableunknown_status
NCT04565236
A Post Approval Commitment Study to Gain More Information on How Safe and Effective KOVALTRY is in Chinese Children, Adolescents /Adults With Severe Hemophilia Atreatment4completed
NCT03370913
Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (BMN 270-301)treatment3active_not_recruiting
NCT05281718
Factor IX as Adjunctive Therapy to Emicizumab (EMIX)basic_science0recruiting
NCT02634918
Ultrasonography in Hemophilic Joint Disease and Serum MarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT01775618
Safety and Efficacy of BAY94-9027 in Previously Treated Male Children With Haemophilia Atreatment3completed
NCT05754619
Emotions in the Communication and Relationship Styles of Parents With Hemophilic Children.No drug interventionsNot AvailableNot Availablerecruiting
NCT00162019
Pharmacokinetics, Efficacy and Safety Study of IMMUNATE SD (Human Plasma-Derived Coagulation Factor VIII Concentrate) in Hemophilia A Patientsdiagnostic3completed
NCT02093741
ADVATE 2 mL Post-Authorization Safety Surveillance (PASS)Not AvailableNot Availablecompleted
NCT00879541
Study of a pd vWF/FVIII, Biostate®, in Subjects With Haemophilia Atreatment2completed
NCT03248141
Understanding Hemophilia A and B Drug Dosage Administration PatternsNo drug interventionsNot AvailableNot Availableterminated
NCT01571934
Inhibitor Development in Patients With Hemophilia A Undergoing SurgeryNo drug interventionsNot AvailableNot Availablecompleted
NCT05804734
Vitamin K Antagonist Versus Direct Oral Anticoagulant Treatments in HemophiliaNot AvailableNot Availablecompleted
NCT04158934
A Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia ANot AvailableNot Availableactive_not_recruiting
NCT05279924
Outcomes of Prophylaxis With Emicizumab in Children With Severe Hemophilia A in Ivory CoasttreatmentNot Availablecompleted
NCT04621916
Preventing Inhibitor Recurrence Indefinitelyprevention4active_not_recruiting
NCT00989196
Clinical Study to Investigate the Pharmacokinetics, Efficacy, Safety and Immunogenicity of a Recombinant FVIII in Patients With Severe Hemophilia Atreatment2completed
NCT01233258
A Trial to Compare Prophylaxis Therapy to On-demand Therapy With a New Full Length Recombinant FVIII in Patients With Severe Hemophilia Atreatment3completed
NCT04085458
Study to Gain More Information on How Safe and Effective Jivi Works in Patients With Severe Hemophilia A (Post-marketing Investigation)treatment4completed
NCT05395858
A Study to Learn More About Treatment With Damoctocog Alfa Pegol, How it is Used in Every Day Practice ("Real-World"), and How Satisfied People Who Receive Damoctocog Alfa Pegol Are in United States (US) Hemophilia Treatment CentersNo drug interventionsNot AvailableNot Availableterminated
NCT00038935
Study Evaluating BDDRFVIII and ReFacto AF in Hemophilia Atreatment3completed
NCT06185335
A Trial of the Safety and Efficacy of Single-Dose Administration of ANB-010 in Subjects With Hemophilia ANo drug interventionstreatment1 / 2recruiting
NCT05911763
A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia ANot AvailableNot Availablerecruiting
NCT03818763
Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia Atreatment1recruiting
NCT05636163
Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio in Predicting the Incidence of Nausea and VomitingNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00002386
Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males With Hemophiliatreatment4completed
NCT04091386
Study to Learn More About the Physical Activity Level of Patients Suffering From Hemophilia A Treated With Damoctocog Alfa Pegol (LIFE ACTIVE Study)Not AvailableNot Availableactive_not_recruiting
NCT05768386
A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)No drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04461639
Study to Learn More About the Safety of Drug Jivi Over a Long Period of Time in Previously Treated Patients With Hemophilia A (Bleeding Disorder Resulting From a Lack of FVIII) Who Are Receiving Jivi Regularly at Their Treating Doctors to Prevent BleedingNot AvailableNot Availableactive_not_recruiting
NCT01653639
Comparative Pharmacokinetic Study of Two Different Strengths of BAY14-2222treatment1completed
NCT03824522
Post Marketing Surveillance Study for ADYNOVATE in South KoreaNot AvailableNot Availablecompleted
NCT00952822
Pharmacokinetic Study of ADVATE Reconstituted in 2 mL Sterile Water for Injectionother1completed
NCT04583930
Clinical and Health-related Outcome of rFVIIIFc ProphylaxisNo drug interventionsNot AvailableNot Availableunknown_status
NCT01589848
Study on Von Willebrand Disease and Hemophilia in Cuenca, EcuadorNo drug interventionsNot AvailableNot Availablecompleted
NCT04158648
A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Emicizumab in Participants With Mild or Moderate Hemophilia A Without FVIII Inhibitorstreatment3active_not_recruiting
NCT00157157
Efficacy and Safety Study of a Recombinant Protein-Free Manufactured Factor VIII (rAHF-PFM) in Previously Untreated Hemophilia A PatientsNo drug interventionstreatment3completed
NCT06104826
Health-Related Quality of Life Outcomes and Bleeding Rates Among Patients With Severe Hemophilia A on EmicizumabNot AvailableNot Availablenot_yet_recruiting
NCT05856266
An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog AlfaNo drug interventionsother4terminated
NCT01810666
Prophylaxis Versus on Demand Treatment for Children With Hemophilia Atreatment4completed
NCT05752565
Physical Activity and FVIII Elimination: Relevance to Personalized Therapy in Severe Hemophilia ANo drug interventionsotherNot Availablecompleted
NCT03006965
Pharmacokinetic Characterization of the Hemophilia A Population in Spain Using myPKFiT®Not AvailableNot Availablecompleted
NCT02093065
Platelet Function in Patients With Hemophilia ANo drug interventionsNot AvailableNot Availablecompleted
NCT02280265
Efficacy and Safety of ADVATE Standard Prophylaxis to Hemophilia AtreatmentNot Availableunknown_status
NCT03392974
Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kgtreatment3completed
NCT05687474
Baby Detect : Genomic Newborn ScreeningNo drug interventionsNot AvailableNot Availablerecruiting
NCT05454774
A Study of FVIII Gene Therapy for Hemophilia ANo drug interventionstreatment0not_yet_recruiting
NCT04131920
Handheld Ultrasound (HHUS) for Home Use in HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT06014320
Alterations in Coagulation Factor Levels in Patients With End Stage Liver DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00000582
Cooperative Study of Factor VIII Inhibitorstreatment3completed
NCT02851082
Could Physical Activity Help to Counteract the Blood Haemophilia Disturbance? A Pilot Study.No drug interventionstreatmentNot Availablecompleted
NCT04759131
Safety, Efficacy and PK of BIVV001 in Pediatric Patients With Hemophilia Atreatment3completed
NCT03313531
Evaluation of a Standardized Protocol for Thrombin Generation AssayNo drug interventionsNot AvailableNot Availablecompleted
NCT00621673
Assessment of the Risk of Inhibitor Formation in Previously Treated Patients With Severe Hemophilia Asupportive_care4terminated
NCT02554773
An Open-label Extension Study of an Investigational Drug, Fitusiran, in Patients With Moderate or Severe Hemophilia A or Btreatment1 / 2completed
NCT06145373
A Study to Test a Medicine (Fitusiran) for Preventing Bleeds in People With Severe Hemophilia Who Previously Received Preventive Treatment With Emicizumabtreatment1recruiting
NCT00623727
BAY79-4980 Compared to rFVIII-FS in Previously Treated Patients With Severe Hemophilia Atreatment2terminated
NCT00002276
The Effects of AZT and Ibuprofen on HIV-Infected Patients With HemophiliatreatmentNot Availablecompleted
NCT05487976
Clinical Study of Recombinant Human Activated Coagulation Factor VII for Injection in Patients With Hemophilia With Inhibitortreatment3unknown_status
NCT03020160
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia Aprevention3completed
NCT02210091
BAX 855 Pediatric Studytreatment3completed
NCT02615691
A Study of PEGylated Recombinant Factor VIII (BAX855) in Previously Untreated Young Children With Severe Hemophilia Atreatment3active_not_recruiting
NCT02396862
Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its TreatmentNot AvailableNot Availablecompleted
NCT05936580
Nuwiq Dosing and Outcomes In the ManagEment of Women/Girls With Haemophilia A Needing FVIII Treatment for Surgerytreatment4recruiting
NCT03915080
Optimizing the Use of Prophylaxis in Patients With Severe Haemophilia Aother4completed
NCT02402829
A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and VenipunctureNo drug interventionsNot AvailableNot Availableterminated
NCT02284789
Colorado Adult Joint Assessment Scale (CAJAS) ValidationNo drug interventionsNot AvailableNot Availablecompleted
NCT05580692
A Prospective Study Evaluating Seroprevalence and Seroconversion of Antibodies Against Adeno-associated Virus (AAV)No drug interventionsotherNot Availableterminated
NCT00037544
Study Evaluating ReFacto AF in Severe Hemophilia Atreatment3completed
NCT06369740
Case and Use Scenario Study to Gain Knowledge on the User Needs for a Medical Device for Hemophilia A MonitoringNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05042440
Pharmacokinetic Assessment of Standard Half-Life (SHL) FVIII, Extended Half-Life (EHL) FVIII, and Efanesoctocog Alfa (BIVV001) in Severe Hemophilia Atreatment1completed
NCT03947567
Safety and Efficacy of Long-term Treatment With SCT800 in Previously Treated Hemophilia A Patients.prevention4recruiting
NCT02795767
A Study of Emicizumab Administered Subcutaneously (SC) in Pediatric Participants With Hemophilia A and Factor VIII (FVIII) Inhibitorstreatment3completed
NCT00927667
Joint Status in Subjects With Severe Hemophilia A in Relation to Different Treatment RegimensNo drug interventionsdiagnostic4completed
NCT05265767
Hematopoietic Stem Cell Transplantation Gene Therapy for Treatment of Severe Hemophilia Atreatment1completed
NCT03932201
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia ANot AvailableNot Availableactive_not_recruiting
NCT03061201
A Study of Recombinant AAV2/6 Human Factor 8 Gene Therapy SB-525 (PF-07055480) in Subjects With Severe Hemophilia Atreatment2completed
NCT01748201
Viscosupplementation in Patients With Hemophilic ArthropathyNo drug interventionstreatment4completed
NCT00005304
Delta Hepatitis and Liver Disease in HemophiliacsNo drug interventionsNot AvailableNot Availablecompleted
NCT03370172
A Study of BAX 888 in Male Adults With Severe Hemophilia Aprevention1 / 2active_not_recruiting
NCT03169972
ADYNOVATE Drug Use-Results SurveyNot AvailableNot Availablecompleted
NCT01386268
Kogenate FS Regulatory Post-Marketing SurveillanceNot AvailableNot Availablecompleted
NCT02581969
Extension at 10 Years of the: "Observational Study Evaluating Efficacy and Costs of Secondary Prophylaxis vs On-demand Therapy With Kogenate Bayer in Patients With Severe Haemophilia A."Not AvailableNot Availablecompleted
NCT00995046
Individually Tailored Prophylaxis in Patients With Severe Hemophilia ANo drug interventionsNot AvailableNot Availableterminated
NCT03520712
Gene Therapy Study in Severe Hemophilia A Patients With Antibodies Against AAV5treatment1 / 2active_not_recruiting
NCT02282410
Evaluate Efficacy and Safety of ADVATE in the Standard Prophylaxis Treatment of Severe or Moderately Severe Hemophilia AtreatmentNot Availableunknown_status
NCT02362581
Comparison of Prophylaxis and On-demand Treatment in Children With Moderate to Severe Hemophilia ANo drug interventionstreatmentNot Availablecompleted
NCT04418414
Hematopoietic Stem Cell Transplantation Gene Therapy for Treatment of Severe Hemophilia ANo drug interventionstreatment1not_yet_recruiting
NCT00632814
Russian Kogenate Pediatric Studytreatment4completed
NCT03315455
Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participantstreatment3active_not_recruiting
NCT01217255
Comparing the Burden of Illness of Hemophilia in the Developing and the Developed WorldNo drug interventionsNot AvailableNot Availablecompleted
NCT00375323
Recombinant Factor VIIa (NovoSeven) on Restoring Coagulation ActivationNot Available3completed
NCT02888223
Pharmacokinetic Study of SCT800 in Previously Treated Patients With Hemophilia Atreatment1unknown_status
NCT00581438
Study Evaluating Approach to Treatment of Haemophilia A and B in SpainNo drug interventionsNot AvailableNot Availablecompleted
NCT00141843
Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia ANo drug interventionsprevention3completed