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Displaying results 811 - 820 of 10000 in total
  1. Drug

    Gabapentin

    go.drugbank.com/drugs/DB00996
    ApprovedInvestigational

    [L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain. … [A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism

    Mixtures: Innoprax-5, GAVINDO NSynonyms: 1-(Aminomethyl)cyclohexaneacetic acid
  2. Drug

    Ibuprofen

    go.drugbank.com/drugs/DB01050
    ApprovedInvestigational

    In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.[A39194] … Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase.

    Synonyms: (±)-α-methyl-4-(2-methylpropyl)benzeneacetic acid, (±)-2-(p-isobutylphenyl)propionic acidInternational brands: Act-3, Alges-X
  3. Target

    Excretory Secretory (ES) proteins

    go.drugbank.com/bio_entities/BE0009630
    TargetFasciola hepatica

    Synonyms: Glutathione S-transferase omega classPolypeptides: Glutathione S-transferase omega class
  4. Target

    Laminin subunit gamma-1

    go.drugbank.com/bio_entities/BE0002107
    TargetHumans

    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a su...

    Synonyms: S-LAM gamma, S-laminin subunit gamma
  5. Drug

    Guaifenesin

    go.drugbank.com/drugs/DB00874
    ApprovedInvestigationalVet approved

    used as an expectorant [F4525]. … Guaifenesin possesses a storied history, having been originally formally approved by the US FDA in 1952 and continues to be one of very few - if not perhaps the only drug that is readily available and

    Mixtures: Pancold S, Colcol-SInternational brands: Sinumist-SR, Duratuss G
  6. Target

    Kynurenine--oxoglutarate transaminase 3

    go.drugbank.com/bio_entities/BE0002162
    TargetHumans

    May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.

    Synonyms: Cysteine-S-conjugate beta-lyase 2Function: cysteine-S-conjugate beta-lyase activity
  7. Target

    Nitric oxide synthase 1

    go.drugbank.com/bio_entities/BE0000067
    TargetEnzymeHumans

    Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR

    Synonyms: Peptidyl-cysteine S-nitrosylase NOS1
  8. Target

    4-aminobutyrate aminotransferase, mitochondrial

    go.drugbank.com/bio_entities/BE0000253
    TargetEnzymeHumans

    Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine...

    Synonyms: (S)-3-amino-2-methylpropionate transaminaseFunction: (S)-3-amino-2-methylpropionate
  9. Target

    Cyclopropane mycolic acid synthase MmaA2

    go.drugbank.com/bio_entities/BE0002512
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  10. Drug

    Netarsudil

    go.drugbank.com/drugs/DB13931
    ApprovedInvestigational

    solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous

    Synonyms: (4-((1S)-1-(Aminomethyl)-2-(isoquinolin-6-ylamino)-2-oxoethyl)phenyl)methyl 2,4- dimethylbenzoate