Nitric oxide synthase 1

BE0000067ProteinHumansNOS1

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. It is acted on by 39 drugs in DrugBank.

Gene name
NOS1
UniProtKB entry
P29475Swiss-Prot
Cellular location
Cell membrane, sarcolemma
Residues / weight
1,434 residues · 160,969 Da
Also known as
1.14.13.39 · bNOS · Constitutive NOS · N-NOS · NC-NOS

Resolves to

Protein
UniProtP29475UniProt nameNOS1_HUMAN
Gene
HGNCHGNC:7872NCBI Gene4842GenBank642526GeneCardsNOS1
Pharmacology
IUPHAR/GtoPdb1251KEGGhsa:4842
Structure
PDB4D1NPDB4UCHPDB4UH5
Drugs

What you can answer from here — as of September 03, 2024

39DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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20GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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90+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nitric oxide synthase 1, how selective are they, and which programs against it are still in active trials?

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