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Deferiprone
go.drugbank.com/drugs/DB08826ApprovedInvestigationalFDA approved on October 14, 2011. … Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs.
Categories: Compounds used in a research, industrial, or household settingHydrocortisone
go.drugbank.com/drugs/DB00741ApprovedInvestigationalVet approved[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574] … [L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.
Mixtures: Oto End 10, HYDROCORTISONE 1% ET UREA 5% CREAMSynonyms: (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dioneVarenicline
go.drugbank.com/drugs/DB01273ApprovedInvestigationalIn addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. … Pfizer is conducting an additional safety study of the drug, results of which are expected in late 2015.
Categories: Drugs Used in Addictive Disorders, Drugs Used in Nicotine DependenceEteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigational[A244930] It is caused by loss-of-function mutations in the DMD gene coding for dystrophin, an essential protein involved in maintaining the structural integrity and function of muscle fibres. … Eteplirsen was first approved by the FDA in September 2016 for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene, which codes for dystrophin, that
Categories: Compounds used in a research, industrial, or household settingSynonyms: N-dimethylphosphonamidate) RNA, dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl)-1-piperazinyl)-N,Pafolacianine
go.drugbank.com/drugs/DB15413ApprovedInvestigational[A242572] On November 29, 2021, the FDA approved pafolacianine as an adjunct imaging agent for intraoperative identification of malignant lesions in adult patients with ovarian cancer. … Pafolacianine targets the folate receptor alpha (FRα) which is upregulated in numerous epithelial malignancies.
Categories: Compounds used in a research, industrial, or household settingCalcium carbimide
go.drugbank.com/drugs/DB09116ApprovedWithdrawnCalcium carbimide, sold as the citrate salt, is an alcohol-sensitizing agent. … [A31516] This drug was developed by Lederle Cyanamid Canada Inc and approved for marketing in Canada in 1959. The current status of calcium carbimide is cancelled post marketing.[L1113]
Categories: Drugs Used in Addictive Disorders, Drugs Used in Alcohol DependenceCilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalIt is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States. … Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It belongs to the angiotensin-converting enzyme inhibitors (ACE inhibitors) class of drugs.
Categories: Agents Acting on the Renin-Angiotensin SystemCaffeine
go.drugbank.com/drugs/DB00201ApprovedInvestigational[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. … [A187694] Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.[T716]
Mixtures: Anacin ES, Re-action ECalaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalAsparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. … Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) [A40270].
Categories: Compounds used in a research, industrial, or household settingDorzolamide
go.drugbank.com/drugs/DB00869ApprovedInvestigational[L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. … [A1304] First marketed in 1995,[A190624] dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt [L11377] or in combination with [timolol] as Cosopt PF.[L11380]
Mixtures: DORZOLAMIDE E TIMOLOLO EG, DORZOLAMIDE E TIMOLOLO EG