Search
Allopurinol
go.drugbank.com/drugs/DB00437ApprovedInvestigationalIt was initially approved by the FDA in 1966 [L5674] and is now formulated by several manufacturers [L5677]. … Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints [A175942].
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Heterocyclic Compounds, 2-RingSynonyms: 1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxypyrazolo(3,4-d)pyrimidineIsosorbide dinitrate
go.drugbank.com/drugs/DB00883ApprovedInvestigationalA vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Categories: Vasodilators Used in Cardiac Diseases, Cytochrome P-450 CYP2E1 InhibitorsSynonyms: D-Isosorbide dinitrateChronic Phase Chronic Myeloid Leukemia
go.drugbank.com/conditions/DBCOND0057382Synonyms: Chronic myelogenous leukemia, no ICD-O subtype, Chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality)Pyroglutamyl-peptidase 1
go.drugbank.com/bio_entities/BE0020171TargetHumansRemoves 5-oxoproline from various penultimate amino acid residues except L-proline
Synonyms: PAP-I, PGP-IMyeloblastic Leukemia
go.drugbank.com/conditions/DBCOND0042219Drugs: DaunorubicinSynonyms: Myeloid leukemia, no ICD-O subtype (morphologic abnormality), Myeloid leukemia, no International Classification of Diseases for Oncology subtypeDapagliflozin
go.drugbank.com/drugs/DB06292ApprovedInvestigational[A261601] Dapagliflozin was originally approved by the FDA on Jan 08, 2014, to improve glycemic control in adults with type 2 diabetes in conjunction with diet and exercise. … [A261596] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron and causing glycosuria
Mixtures: XIGLIF-M, PLEMTUM-MCategories: Drugs Used in Diabetes, P-glycoprotein substratesSitagliptin
go.drugbank.com/drugs/DB01261ApprovedInvestigationalSitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].
Mixtures: Nb-sitagliptin-metformin, Nb-sitagliptin-metforminCategories: DPP-IV Inhibitors, Drugs Used in DiabetesAminoglycoside 3'-phosphotransferase
go.drugbank.com/bio_entities/BE0003548EnzymeEscherichia coliResistance to kanamycin and structurally-related aminoglycosides, including amikacin.
Synonyms: APH(3')I, APH(3')-IPaclitaxel
go.drugbank.com/drugs/DB01229ApprovedInvestigationalVet approvedIt is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane. … Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexSynonyms: 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine, Taxol APseudohypoparathyroidism
go.drugbank.com/conditions/DBCOND0008696Drugs: DihydrotachysterolSynonyms: Pseudohypoparathyroidism type I A (disorder)