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Displaying results 841 - 850 of 3387 in total
  1. Target

    Killer cell immunoglobulin-like receptor 2DL2

    go.drugbank.com/bio_entities/BE0010848
    TargetHumans

    Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis

    Polypeptides: Killer cell immunoglobulin-like receptor 2DL2Synonyms: p58 NK receptor CL-43, p58 natural killer cell receptor clone CL-43
  2. Target

    Killer cell immunoglobulin-like receptor 3DL2

    go.drugbank.com/bio_entities/BE0010849
    TargetHumans

    Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). … Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464)

    Polypeptides: Killer cell immunoglobulin-like receptor 3DL2Synonyms: p70 NK receptor CL-5, p70 natural killer cell receptor clone CL-5
  3. Target

    Interleukin-22 receptor subunit alpha-1

    go.drugbank.com/bio_entities/BE0016650
    TargetHumans

    Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. … Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation.

    Polypeptides: Interleukin-22 receptor subunit alpha-1Synonyms: IL-22 receptor subunit alpha-1, Cytokine receptor class-II member 9
  4. Target

    Taste receptor type 2 member 3

    go.drugbank.com/bio_entities/BE0023234
    TargetHumans

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

    Polypeptides: Taste receptor type 2 member 3Function: bitter taste receptor activity
  5. Target

    T cell receptor beta variable 13

    go.drugbank.com/bio_entities/BE0023663
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor beta variable 13
  6. Target

    T cell receptor delta variable 2

    go.drugbank.com/bio_entities/BE0023749
    TargetHumans

    V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor delta variable 2
  7. Drug

    Coagulation factor X human

    go.drugbank.com/drugs/DB13148
    ApprovedInvestigational

    Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. However its use is limited in the perioperative setting for th...

    Mixtures: UMAN COMPLEX, UMAN COMPLEX
  8. Drug

    PX-478

    go.drugbank.com/drugs/DB06082
    Investigational

    PX-478 was effective in models of both non-small cell lung cancer and small cell lung cancer that express HIF-1 alpha. … PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical trial in patients with advanced metastatic cancer and lymphoma.

  9. Drug

    Calcium glycerophosphate

    go.drugbank.com/drugs/DB11264
    Approved

    It is suggested that calcium glycerophosphate promotes plaque-pH buffering, elevation of plaque [DB01373] and phosphate levels and direct interaction with dental mineral [A27153].

  10. Target

    G protein-coupled receptor kinase 3

    go.drugbank.com/bio_entities/BE0000018
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).

    Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2