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Crizotinib
go.drugbank.com/drugs/DB08865ApprovedInvestigational[A250785] Crizotinib was approved by the FDA in 2011, and its use is accompanied by FDA-approved tests used to detect ALK and ROS1 rearrangements.[L42460] … Second- and third-generation ALK-tyrosine kinase-inhibitors have overcome many of the pharmacodynamic and genetic resistance mechanisms crizotinib is prone to.
Categories: Antineoplastic and Immunomodulating AgentsProducts: Xalkori Capsules 250mg, Xalkori 250mg Hard CapsulesThioproperazine
go.drugbank.com/drugs/DB01622ApprovedIt is virtually without antiserotonin and hypotensive action and has no antihistaminic property. … It is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Synonyms: N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide, N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamideProducts: Majeptil Tab 10mgDuloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigationalDuloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. … Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.
Synonyms: (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amineCategories: Serotonin and Noradrenaline Reuptake Inhibitors, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeAcyclovir
go.drugbank.com/drugs/DB00787ApprovedInvestigationalAcyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis. … [L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.
Categories: Acyclovir and prodrug, Nucleosides and NucleotidesProducts: DBL ACICLOVIR INTRAVENOUS INFUSION 250mg/10ml, ACICLOVIR HOSPIRA 25MG/MLAmbrisentan
go.drugbank.com/drugs/DB06403ApprovedInvestigationalIt is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. … In addition, it is approved in the United States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and to improve exercise ability.
Categories: ambrisentan and tadalafilProducts: AMBRISEN 1A PHARMA 10MG, AMBRISENTAN ACCORD 10MGRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnCytochrome P450 1A2, Cytochrome P450 3A4, Cytochrome P450 2C9, Cytochrome P450 2C8, and Prostaglandin G/H synthase 1 are known to metabolize rofecoxib. … Rofecoxib has a half-life of 17 hours and its mean oral bioavailability at therapeutically recommended doses of 125, 25, and 50 mg is approximately 93%.
Categories: Antiinflammatory and Antirheumatic Products, Non-Steroids, Antiinflammatory and Antirheumatic ProductsProducts: Vioxx Tab 25mg, ROFECOXIB 25MGTetryzoline
go.drugbank.com/drugs/DB06764Approved[A7045, A231769] It has also been misused for non-therapeutic purposes as a causative drug for several cases of drug-facilitated sexual assault.[A231764] … [A231769] Available since the 1950s, tetryzoline is a selective α<sub>1</sub>-receptor agonist [A231774] that is used as an ocular and nasal decongestant.
Mixtures: Up and Up Ultra Itchy Relief, Redness reliever and LubricantCategories: Decongestants and Antiallergicsgamma-Aminobutyric acid
go.drugbank.com/drugs/DB02530ApprovedInvestigationalThe most common inhibitory neurotransmitter in the central nervous system.
Mixtures: Medi-doze Sleep Aid, Medi-doze Rx Sleep AidCategories: Amino Acids, Peptides, and ProteinsFluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. … Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
Products: Lescol 20mg, FLUVASTATIN HEXAL 20MGMebendazole
go.drugbank.com/drugs/DB00643ApprovedInvestigationalVet approvedA benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]
Categories: Antiparasitic Products, Insecticides and RepellentsProducts: PIPERAWITT NF, PRIMEDAZOL TABLET 100MG