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Drotrecogin alfa
go.drugbank.com/drugs/DB00055ApprovedWithdrawnDrotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis. … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.
Products: Xigris (20mg/vial), Xigris (5mg/vial)Racecadotril
go.drugbank.com/drugs/DB11696InvestigationalRacecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Products: Hidrasec Infants 10mg Granules for Oral Suspension, Hidrasec Infants Granules for Oral Suspension 10mgEntrectinib
go.drugbank.com/drugs/DB11986ApprovedInvestigational[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. … [L8207] Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval based on early trial data.
Products: ROZLYTREK HARD CAPSULE 100MG, ROZLYTREK CÁPSULAS DURAS 100MGOcrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigationalIt was later approved by Health Canada in August 2017, making the drug the first available treatment for PPMS in both the US and Canada. … [L42895] It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen.
Products: OCREVUS 300mg/10mL Concentrate for Solution for Infusion, OCREVUS® CONCENTRADO PARA SOLUCION PARA INFUSION 300MG/10MLCod liver oil
go.drugbank.com/drugs/DB11321ApprovedNutraceuticalVet approvedIt is used as an adjunct treatment and preventative therapy of rickets, osteomalacia and osteoporosis while meeting the consumption criteria. … Also being a rich source of vitamin A and D, cod liver oil can be taken orally as daily supplements.
Products: NATURALLE COD LIVER OIL 275MG SOFTGEL CAPSULEInsulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalAfrezza does not currently have Health Canada or European Medicines Agency approval for marketing in Canada or the EU. … While still available in the US, Afrezza has had similar concerns associated with its use, and had an FDA "black box" warning added to it to warn about use in patients with chronic lung disease.
Mixtures: INSUMAN COMB 25 100I E/ML, INSUMAN COMB 25 100I E/MLProducts: INSULATARD 100IU/ML,10ML, MIXTARD 30,100IU/ML,10MLNitroprusside
go.drugbank.com/drugs/DB00325ApprovedInvestigationalNitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles).
Products: NITROPRUSIATO DE SODIO USP 25MG/ML, DBL SODIUM NITROPRUSSIDE INJECTION 50mg/2mlTerfenadine
go.drugbank.com/drugs/DB00342ApprovedWithdrawnIn the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Products: Seldane Tab 60mg, Seldane - Tab 60mgRoxithromycin
go.drugbank.com/drugs/DB00778ApprovedInvestigationalWithdrawnIt is marketed in Australia as a treatment for respiratory tract, urinary and soft tissue infections. … It was shown to be more effective against certain Gram-negative bacteria, particularly _Legionella pneumophila_.
International brands: Le Er Tai, Heng TeProducts: ROXIHEXAL 50MG, ROXIHEXAL 150MGSarilumab
go.drugbank.com/drugs/DB11767ApprovedInvestigational[A27262] Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe rheumatoid … [A27264] Subcutaneous administration of sarilumab has been shown to decrease acute-phase reactant levels and improve clinical RA symptoms.[A27263]
Products: KEVZARA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG, KEVZARA Solution for Injection in Pre-filled Pen 150mg