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Isoflurophate
go.drugbank.com/drugs/DB00677ApprovedWithdrawnIt is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically.
Synonyms: O,O'-diisopropyl phosphoryl fluorideAmphotericin B
go.drugbank.com/drugs/DB00681ApprovedInvestigationalWhile Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. … Amphotericin B shows a high order of in vitro activity against many species of fungi.
Synonyms: AMPH-b, Amfotericina BSalts: Amphotericin B Cholesteryl Sulfate ComplexTobramycin
go.drugbank.com/drugs/DB00684ApprovedInvestigationalsuch as β-lactams and cephalosporins. … [A232294] Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics
Mixtures: Tobradex ST, Tobradex STCategories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexFludrocortisone
go.drugbank.com/drugs/DB00687ApprovedInvestigational[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position … Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ASTONIN® H TABLETAS, Astonin - H - TablettenMycophenolate mofetil
go.drugbank.com/drugs/DB00688ApprovedInvestigationalMycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … [A180805] This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoateCephaloglycin
go.drugbank.com/drugs/DB00689ApprovedA cephalorsporin antibiotic that is no longer commonly used.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 7-(D-2-Amino-2-phenylacetamido)-3-acetoxymethyl-delta(sup3)-cephem-4-carboxylic acid, 7-(2-D-alpha-Aminophenylacetamido)cephalosporanic acidMoexipril
go.drugbank.com/drugs/DB00691ApprovedInvestigationalMoexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension).
Categories: Heterocyclic Compounds, 2-RingFluorescein
go.drugbank.com/drugs/DB00693ApprovedInvestigationalA phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal
Categories: Heterocyclic Compounds, 3-Ring, Compounds used in a research, industrial, or household settingSynonyms: D&C Yellow No. 7, 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenoneTizanidine
go.drugbank.com/drugs/DB00697ApprovedInvestigationalTizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury [T574]. … Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons
Mixtures: ALGI - B® TABLETAS, ALGI - B® TABLETASCategories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesNitrofurantoin
go.drugbank.com/drugs/DB00698ApprovedInvestigationalVet approvedNitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. … [A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830] Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895]
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(5-Nitrofurfurylidene)-1-aminohydantoin, 1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedione