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Romidepsin
go.drugbank.com/drugs/DB06176ApprovedInvestigationalRomidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexPixantrone
go.drugbank.com/drugs/DB06193ApprovedWithdrawninactivity [3]. … It also inhibits doxorubicinol formation in human myocardium. [3] As a result, it is believed to be less cardiotoxic while still exerting efficacy.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dioneIcatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigationalIcatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B<sub>2</sub> receptors with a similar affinity to bradykinin. … It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B<sub>2</sub> receptors antagonists, thus representing a new class of medication.
Products: FIRAZYR®, İKTU 30 MG/3 ML ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETRufinamide
go.drugbank.com/drugs/DB06201ApprovedRufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy.
Categories: Cytochrome P-450 CYP3A Inducers, Heterocyclic Compounds, 1-RingProducts: INOVELON® 400 MGSugammadex
go.drugbank.com/drugs/DB06206ApprovedInvestigationalSugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. … Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery.
Categories: Compounds used in a research, industrial, or household settingProducts: BRIDION® 200 MG/2 ML SOLUCIÓN PARA INYECCIÓN, MIGAD-XTolvaptan
go.drugbank.com/drugs/DB06212ApprovedInvestigationalTolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexVadimezan
go.drugbank.com/drugs/DB06235InvestigationalSynonyms: (5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid, 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acidCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 3-Ring